Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | CASP1 | P29466 | 1/20 | 0.31 |
| ▸ | CASP7 | P55210 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7002215 | 0.84 | PIK3R1 (0.36) | GABRA1GABRA5MEN1KMT2AKDM4E | |
| SCHEMBL7526734 | 0.79 | PIK3R1 (0.35) | PIK3R1PIK3CALMNA | |
| SCHEMBL6854914 | 0.78 | PKM (0.48) | GABRA1GABRA5MEN1KMT2AKDM4E | |
| SCHEMBL6854127 | 0.78 | MAPT (0.43) | KDM4EALDH1A1HPGDCASP1HSD17B10 | |
| SCHEMBL6855211 | 0.77 | PKM (0.49) | GABRA1GABRA5MEN1KMT2AKDM4E | |
| SCHEMBL6855386 | 0.77 | MAPT (0.44) | KDM4EALDH1A1HPGDCASP1HSD17B10 | |
| SCHEMBL7530001 | 0.77 | PDE7A (0.33) | PIK3R1PIK3CAALDH1A1LMNATSHR | |
| SCHEMBL6854433 | 0.76 | PIK3R1 (0.36) | PIK3R1PIK3CAHSD17B10 | |
| SCHEMBL6856311 | 0.76 | SMN1; SMN2 (0.33) | HSD17B10 | |
| SCHEMBL6994280 | 0.75 | DHFR (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1177195-B1 | 1-AMINO TRIAZOLO 4,3-a! QUINAZOLINE-5-ONES AND OR -5-THIONES INHIBITING PHOSPHODIESTERASE IV | WARNER LAMBERT CO (US) | 2003-03-19 | — | — | EP | claimed |