Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6994280 | 0.87 | DHFR (0.31) | DHFR | |
| SCHEMBL6850132 | 0.80 | USP14 (0.33) | — | |
| SCHEMBL7002369 | 0.80 | MAPT (0.39) | DHFR | |
| SCHEMBL7002362 | 0.80 | MAPT (0.39) | DHFR | |
| SCHEMBL6854144 | 0.78 | DHFR (0.42) | DHFR | |
| SCHEMBL6854150 | 0.78 | DHFR (0.42) | DHFR | |
| SCHEMBL7507192 | 0.77 | — | — | |
| SCHEMBL7463534 | 0.77 | — | — | |
| SCHEMBL6994277 | 0.77 | MAPT (0.40) | DHFR | |
| SCHEMBL6994283 | 0.77 | MAPT (0.40) | DHFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1177195-B1 | 1-AMINO TRIAZOLO 4,3-a! QUINAZOLINE-5-ONES AND OR -5-THIONES INHIBITING PHOSPHODIESTERASE IV | WARNER LAMBERT CO (US) | 2003-03-19 | — | — | EP | claimed |
| WO-2000066584-B1 | 1-AMINO TRIAZOLO¢4,3-a! QUINAZOLINE-5-ONES AND OR -5-THIONES INHIBITING PHOSPHODIESTERASE IV | WARNER LAMBERT CO (US) | 2001-02-15 | — | — | WO | claimed |