Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 15/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.32 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.32 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.32 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3568036 | 0.74 | DPP4 (0.38) | GSK3B | |
| SCHEMBL7003368 | 0.72 | MAPK1 (0.39) | GSK3B | |
| SCHEMBL3565612 | 0.69 | KDM4E (0.45) | GSK3BGABRA1GABRG2GABRB3GABRA3 | |
| SCHEMBL7003366 | 0.69 | P2RX7 (0.33) | GSK3B | |
| SCHEMBL6994817 | 0.67 | GSK3B (0.42) | GSK3BCYP2D6 | |
| SCHEMBL3568873 | 0.67 | GSK3B (0.46) | GSK3BCYP2D6 | |
| SCHEMBL3573569 | 0.67 | MEN1 (0.35) | GSK3BCYP2D6 | |
| SCHEMBL3573567 | 0.67 | MEN1 (0.35) | GSK3BCYP2D6 | |
| SCHEMBL3573572 | 0.67 | MEN1 (0.35) | GSK3BCYP2D6 | |
| SCHEMBL3566871 | 0.65 | GSK3B (0.49) | GSK3BCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1340760-A1 | Substituted 2-pyrimidinyl-6,7,8,9-tetrahydropyrimido[1,2-a]pyrimidin-4-one and 7-pyrimidinyl-2,3-dihydroimidazo[1,2-a]pyrimidin-5(1H)one derivatives | SANOFI-SYNTHELABO (FR) | 2003-09-03 | — | — | EP | disclosed |
| EP-1295884-A1 | 2-pyrimidinyl-6,7,8,9-tetrahydropyrimido[1,2-a]Pyrimidin-4-one and 7-Pyrimidinyl-2,3-Dihydroimidazo[1,2-a]Pyrimidin-5(1H)one derivatives | SANOFI-SYNTHELABO (FR) | 2003-03-26 | — | — | EP | disclosed |