Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 10/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | DHPS | P49366 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3573569 | 0.81 | MEN1 (0.35) | MAPK1GSK3BMEN1KMT2A | |
| SCHEMBL3573567 | 0.81 | MEN1 (0.35) | MAPK1GSK3BMEN1KMT2A | |
| SCHEMBL3573572 | 0.81 | MEN1 (0.35) | MAPK1GSK3BMEN1KMT2A | |
| SCHEMBL7003366 | 0.80 | P2RX7 (0.33) | GSK3B | |
| SCHEMBL7002558 | 0.72 | GSK3B (0.35) | GSK3B | |
| SCHEMBL3577522 | 0.69 | KDM4E (0.45) | GSK3B | |
| SCHEMBL6995827 | 0.68 | GSK3B (0.43) | GSK3B | |
| SCHEMBL4872091 | 0.67 | GSK3B (0.38) | MAPK1GSK3BMEN1KMT2A | |
| SCHEMBL4872096 | 0.67 | GSK3B (0.38) | MAPK1GSK3BMEN1KMT2A | |
| SCHEMBL4872083 | 0.67 | GSK3B (0.38) | MAPK1GSK3BMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1340760-A1 | Substituted 2-pyrimidinyl-6,7,8,9-tetrahydropyrimido[1,2-a]pyrimidin-4-one and 7-pyrimidinyl-2,3-dihydroimidazo[1,2-a]pyrimidin-5(1H)one derivatives | SANOFI-SYNTHELABO (FR) | 2003-09-03 | — | — | EP | disclosed |
| EP-1295884-A1 | 2-pyrimidinyl-6,7,8,9-tetrahydropyrimido[1,2-a]Pyrimidin-4-one and 7-Pyrimidinyl-2,3-Dihydroimidazo[1,2-a]Pyrimidin-5(1H)one derivatives | SANOFI-SYNTHELABO (FR) | 2003-03-26 | — | — | EP | disclosed |