Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 8/20 | 0.46 |
| ▸ | ERBB2 | P04626 | 6/20 | 0.46 |
| ▸ | SRC | P12931 | 2/20 | 0.46 |
| ▸ | STK4 | Q13043 | 10/20 | 0.44 |
| ▸ | STK3 | Q13188 | 1/20 | 0.41 |
| ▸ | MAP3K8 | P41279 | 1/20 | 0.40 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6997292 | 0.86 | EGFR (0.46) | EGFRERBB2SRCSTK4STK3 | |
| SCHEMBL2207583 | 0.84 | EGFR (0.65) | EGFRERBB2SRCSTK4MAP2K1 | |
| SCHEMBL6999506 | 0.83 | EGFR (0.42) | EGFRERBB2SRCSTK4STK3 | |
| SCHEMBL6384516 | 0.82 | EGFR (0.54) | EGFRERBB2SRCSTK4MAP2K1 | |
| SCHEMBL6385221 | 0.81 | STK4 (0.55) | EGFRERBB2SRCSTK4MAP2K1 | |
| SCHEMBL6994510 | 0.81 | PRKCQ (0.51) | EGFRERBB2SRC | |
| SCHEMBL6997780 | 0.81 | MAPT (0.46) | EGFRERBB2SRCSTK4STK3 | |
| SCHEMBL7002440 | 0.81 | ALDH1A1 (0.47) | EGFRERBB2SRCSTK4 | |
| SCHEMBL6384070 | 0.81 | EGFR (0.71) | EGFRERBB2SRCSTK4STK3 | |
| SCHEMBL6991527 | 0.81 | PRKCQ (0.50) | EGFRERBB2SRCSTK4STK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1117659-B1 | SUBSTITUTED 3-CYANOQUINOLINES AS PROTEIN TYROSINE KINASES INHIBITORS | WYETH CORP (US) | 2003-12-03 | — | — | EP | claimed |