Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | TNKS | O95271 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7001485 | 1.00 | KMT2A (0.37) | KMT2AMEN1TNKSMAPTRAB9A | |
| SCHEMBL7001430 | 0.86 | CYP17A1 (0.42) | KMT2AMEN1CACNA1ISLC6A2SLC6A4 | |
| SCHEMBL7001444 | 0.86 | CYP17A1 (0.42) | KMT2AMEN1CACNA1ISLC6A2SLC6A4 | |
| SCHEMBL7002770 | 0.79 | ACHE (0.40) | KMT2AMEN1MAPTSLC6A2SLC6A4 | |
| SCHEMBL6999668 | 0.79 | ACHE (0.40) | KMT2AMEN1MAPTSLC6A2SLC6A4 | |
| SCHEMBL7001280 | 0.74 | SLC6A2 (0.43) | RAB9AL3MBTL1LMNASLC6A2SLC6A4 | |
| SCHEMBL6996545 | 0.74 | SLC6A2 (0.43) | RAB9AL3MBTL1LMNASLC6A2SLC6A4 | |
| SCHEMBL7000321 | 0.68 | NOS3 (0.39) | ADRA2ACYP2D6CYP2C19 | |
| SCHEMBL7000870 | 0.68 | NOS3 (0.39) | ADRA2ACYP2D6CYP2C19 | |
| SCHEMBL2086794 | 0.67 | TAAR1 (0.52) | KMT2AMEN1L3MBTL1SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1069132-B1 | Bicyclic derivatives of amino-pyrazinones, process of preparation and pharmaceutical compositions comprising them | SERVIER LAB (FR) | 2003-10-01 | — | — | EP | disclosed |
| US-6277851-B1 | ORALLY ADMINISTERED TRYPSIN-RELATED SERINE PROTEASE INHIBITORS; ANTICOAGULANTS | ADIR ET COMPAGNIE (FR) | 2001-08-21 | — | — | US | disclosed |
| EP-1069132-A1 | Bicyclic derivatives of amino-pyrazinones, process of preparation and pharmaceutical compositions comprising them | ADIR ET COMPAGNIE (FR) | 2001-01-17 | — | — | EP | disclosed |