Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7000260 | 0.83 | SMN1; SMN2 (0.52) | CYP1A2SMN1; SMN2MEN1KMT2AMAPK1 | |
| SCHEMBL6993863 | 0.81 | CYP1A2 (0.49) | CYP1A2SMN1; SMN2MEN1KMT2AMAPK1 | |
| SCHEMBL6993859 | 0.81 | CYP1A2 (0.48) | CYP1A2SMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL6999211 | 0.80 | CYP1A2 (0.48) | CYP1A2SMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL6996336 | 0.80 | TSHR (0.48) | CYP1A2SMN1; SMN2KMT2AMAPK1ALDH1A1 | |
| SCHEMBL25399382 | 0.80 | L3MBTL1 (0.50) | CYP1A2SMN1; SMN2MEN1KMT2AMAPK1 | |
| SCHEMBL6999206 | 0.80 | CYP1A2 (0.47) | CYP1A2SMN1; SMN2MEN1KMT2AL3MBTL1 | |
| SCHEMBL6996330 | 0.79 | TSHR (0.50) | CYP1A2SMN1; SMN2KMT2AMAPK1ALDH1A1 | |
| SCHEMBL6995149 | 0.76 | SMN1; SMN2 (0.52) | CYP1A2SMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL7004142 | 0.76 | ALDH1A1 (0.46) | CYP1A2SMN1; SMN2MEN1KMT2AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1123296-B1 | PYRAZOLOPYRIMIDINONE cGMP PDE5 INHIBITORS FOR THE TREATMENT OF SEXUAL DYSFUNCTION | PFIZER LTD (GB) | 2003-09-17 | — | — | EP | disclosed |
| US-6333330-B1 | Pyrazolopyrimidinone CGMP PDE5 inhibitors for the treatment of sexual dysfunction | PFIZER INC. | 2001-12-25 | — | — | US | disclosed |