Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | PDE1A | P54750 | 1/20 | 0.42 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.42 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.41 |
| ▸ | SLC16A1 | P53985 | 1/20 | 0.41 |
| ▸ | PDE5A | O76074 | 3/20 | 0.40 |
| ▸ | PDE4A | P27815 | 3/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7004143 | 0.94 | SMN1; SMN2 (0.44) | ALDH1A1KDM4EMAPK1HSD17B10SMN1; SMN2 | |
| SCHEMBL7002026 | 0.83 | ALDH1A1 (0.43) | ALDH1A1KDM4EMAPK1HSD17B10SMN1; SMN2 | |
| SCHEMBL6995580 | 0.81 | ADRA1D (0.42) | ALDH1A1KDM4ESMN1; SMN2CYP1A2MEN1 | |
| SCHEMBL1215829 | 0.80 | ELANE (0.51) | ALDH1A1KDM4EMAPK1HSD17B10SMN1; SMN2 | |
| SCHEMBL6993859 | 0.80 | CYP1A2 (0.48) | ALDH1A1KDM4EHSD17B10SMN1; SMN2HPGD | |
| SCHEMBL7000021 | 0.79 | KDM4E (0.41) | ALDH1A1KDM4EMAPK1HSD17B10SMN1; SMN2 | |
| SCHEMBL6996330 | 0.78 | TSHR (0.50) | ALDH1A1KDM4EMAPK1HSD17B10SMN1; SMN2 | |
| Potassium Ion SCHEMBL7823785 | 0.78 | ALDH1A1 (0.40) | ALDH1A1KDM4EMAPK1HSD17B10SMN1; SMN2 | |
| SCHEMBL25399382 | 0.76 | L3MBTL1 (0.50) | ALDH1A1KDM4EMAPK1HSD17B10SMN1; SMN2 | |
| SCHEMBL7002826 | 0.76 | CYP1A2 (0.60) | ALDH1A1KDM4EMAPK1HSD17B10SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1123296-B1 | PYRAZOLOPYRIMIDINONE cGMP PDE5 INHIBITORS FOR THE TREATMENT OF SEXUAL DYSFUNCTION | PFIZER LTD (GB) | 2003-09-17 | — | — | EP | disclosed |
| US-6333330-B1 | Pyrazolopyrimidinone CGMP PDE5 inhibitors for the treatment of sexual dysfunction | PFIZER INC. | 2001-12-25 | — | — | US | disclosed |