Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 5/20 | 0.51 |
| ▸ | ADORA1 | P30542 | 5/20 | 0.51 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.51 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | GMNN | O75496 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7667756 | 0.80 | ADORA1 (0.55) | ADORA2BADORA1ADORA2AADORA3MEN1 | |
| SCHEMBL7000817 | 0.79 | ADORA2A (0.40) | ADORA2BADORA1ADORA2AADORA3MEN1 | |
| SCHEMBL7000589 | 0.79 | ADORA2A (0.40) | ADORA2BADORA1ADORA2AADORA3MEN1 | |
| SCHEMBL4310874 | 0.74 | ADORA1 (0.62) | ADORA2BADORA1ADORA2AADORA3MEN1 | |
| SCHEMBL27713795 | 0.72 | SIRT1 (0.68) | ADORA2BADORA1ADORA2APOLB | |
| SCHEMBL4310870 | 0.72 | ADORA1 (0.62) | ADORA2BADORA1ADORA2AADORA3MEN1 | |
| SCHEMBL6997253 | 0.71 | ADORA2A (0.48) | ADORA2BADORA1ADORA2AADORA3POLB | |
| 1,3-Dipropyl-8-Cyclopentylxanthine [Dpcpx] SCHEMBL382422 | 0.67 | ADORA1 (1.00) | ADORA2BADORA1ADORA2AADORA3MEN1 | |
| SCHEMBL8559082 | 0.67 | ADORA1 (0.62) | ADORA2BADORA1ADORA2AADORA3MEN1 | |
| SCHEMBL8558446 | 0.67 | PDE4A (0.45) | ADORA2BADORA1ADORA2AADORA3MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1087973-B1 | IMIDAZOTRIAZOLOPYRIMIDINES USED AS A DRUG HAVING AN ADENOSINE ANTAGONIST ACTIVITY | BOEHRINGER INGELHEIM PHARMA (DE) | 2003-01-08 | — | — | EP | claimed |
| EP-1087973-A1 | IMIDAZOTRIAZOLOPYRIMIDINES USED AS A DRUG HAVING AN ADENOSINE ANTAGONIST ACTIVITY | Boehringer Ingelheim Pharma KG (DE) | 2001-04-04 | — | — | EP | claimed |
| WO-1999065912-A1 | IMIDAZOTRIAZOLOPYRIMIDINES USED AS A DRUG HAVING AN ADENOSINE ANTAGONIST ACTIVITY | BOEHRINGER INGELHEIM PHARMA KG (DE) | 1999-12-23 | — | — | WO | claimed |
| EP-1087973-B1 | IMIDAZOTRIAZOLOPYRIMIDINES USED AS A DRUG HAVING AN ADENOSINE ANTAGONIST ACTIVITY | BOEHRINGER INGELHEIM PHARMA (DE) | 2003-01-08 | — | — | EP | disclosed |