Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 7/20 | 0.48 |
| ▸ | ADORA2B | P29275 | 5/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6995974 | 0.88 | MEN1 (0.49) | ADORA2AADORA2BADORA3ADORA1 | |
| SCHEMBL8563585 | 0.80 | ADORA2B (0.54) | ADORA2AADORA2BADORA3 | |
| SCHEMBL7002900 | 0.71 | ADORA2B (0.51) | ADORA2AADORA2BADORA3POLBADORA1 | |
| SCHEMBL8872400 | 0.71 | ADORA2B (0.69) | ADORA2AADORA2BADORA1 | |
| SCHEMBL27713795 | 0.69 | SIRT1 (0.68) | ADORA2AADORA2BPOLBADORA1 | |
| SCHEMBL7001673 | 0.69 | SIRT1 (0.47) | ADORA2AADORA2BADORA3POLBADORA1 | |
| SCHEMBL25539381 | 0.65 | ADORA2A (0.58) | ADORA2AADORA2BADORA3ADORA1 | |
| SCHEMBL8769258 | 0.64 | ADORA2A (0.64) | ADORA2AADORA2BADORA1 | |
| SCHEMBL7001583 | 0.64 | ADORA2A (0.49) | ADORA2AADORA2BADORA3 | |
| SCHEMBL1720432 | 0.63 | ADORA2A (0.51) | ADORA2AADORA2BADORA3ADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1087973-B1 | IMIDAZOTRIAZOLOPYRIMIDINES USED AS A DRUG HAVING AN ADENOSINE ANTAGONIST ACTIVITY | BOEHRINGER INGELHEIM PHARMA (DE) | 2003-01-08 | — | — | EP | claimed |
| EP-1087973-A1 | IMIDAZOTRIAZOLOPYRIMIDINES USED AS A DRUG HAVING AN ADENOSINE ANTAGONIST ACTIVITY | Boehringer Ingelheim Pharma KG (DE) | 2001-04-04 | — | — | EP | claimed |
| WO-1999065912-A1 | IMIDAZOTRIAZOLOPYRIMIDINES USED AS A DRUG HAVING AN ADENOSINE ANTAGONIST ACTIVITY | BOEHRINGER INGELHEIM PHARMA KG (DE) | 1999-12-23 | — | — | WO | claimed |
| EP-1087973-B1 | IMIDAZOTRIAZOLOPYRIMIDINES USED AS A DRUG HAVING AN ADENOSINE ANTAGONIST ACTIVITY | BOEHRINGER INGELHEIM PHARMA (DE) | 2003-01-08 | — | — | EP | disclosed |
| US-6492377-B1 | Imidazotriazolopyrimidines with adenosine-antagonistic activity | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2002-12-10 | — | — | US | disclosed |