Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 3/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.45 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.45 |
| ▸ | PDE1A | P54750 | 1/20 | 0.41 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.41 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 7/20 | 0.39 |
| ▸ | ADORA2B | P29275 | 6/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | GMNN | O75496 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | TDP2 | O95551 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7002900 | 0.67 | ADORA2B (0.51) | ADORA2AADORA2BADORA1LMNAMEN1 | |
| SCHEMBL7667756 | 0.63 | ADORA1 (0.55) | ADORA2AADORA2BADORA1LMNAMEN1 | |
| SCHEMBL9287682 | 0.62 | ADORA2A (0.56) | PDE4APDE4BPDE4CPDE4DPDE1A | |
| SCHEMBL3171115 | 0.62 | ADORA2A (0.55) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL8563869 | 0.62 | ADORA1 (0.47) | ADORA2AADORA2BADORA1LMNAMEN1 | |
| SCHEMBL4120049 | 0.61 | ADORA2A (0.54) | PDE4APDE4BPDE4CPDE4DPDE1A | |
| SCHEMBL8559079 | 0.61 | ADORA2B (0.46) | ADORA2AADORA2BADORA1LMNAMEN1 | |
| SCHEMBL1388160 | 0.60 | CTSL (0.34) | PDE4APDE4BPDE4CPDE4DTDP2 | |
| SCHEMBL8559968 | 0.59 | ADORA1 (0.53) | ADORA2AADORA2BADORA1LMNAMEN1 | |
| Hydrochloric Acid SCHEMBL7105815 | 0.59 | CTSL (0.33) | PDE4APDE4BPDE4CPDE4DTDP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0880524-A1 | NEW TRIAZOLOPURINES, METHOD OF PREPARING THEM AND THEIR USE AS DRUGS | Boehringer Ingelheim Pharma KG (DE) | 1998-12-02 | — | — | EP | disclosed |
| WO-1998003511-A1 | NEW TRIAZOLOPURINES, METHOD OF PREPARING THEM AND THEIR USE AS DRUGS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 1998-01-29 | — | — | WO | disclosed |