Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 1/20 | 0.50 |
| ▸ | PI4KA | P42356 | 1/20 | 0.50 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.50 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.50 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.50 |
| ▸ | TNF | P01375 | 1/20 | 0.46 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.46 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.46 |
| ▸ | PDE4A | P27815 | 1/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.44 |
| ▸ | CTSL | P07711 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5744439 | 0.82 | CYP11B1 (0.47) | ADORA2API4KAPI4K2BPI4K2API4KB | |
| SCHEMBL3130833 | 0.77 | ADORA2A (0.47) | ADORA2API4KAPI4K2BPI4K2API4KB | |
| SCHEMBL21199068 | 0.75 | ADORA2A (0.54) | ADORA2API4KAPI4K2BPI4K2API4KB | |
| SCHEMBL6999181 | 0.74 | ADORA2A (0.43) | ADORA2API4KAPI4K2BPI4K2API4KB | |
| SCHEMBL14944602 | 0.73 | CTSL (0.67) | ADORA2API4KAPI4K2BPI4K2API4KB | |
| SCHEMBL1754731 | 0.71 | ADORA2A (0.50) | ADORA2API4KAPI4K2BPI4K2API4KB | |
| SCHEMBL1523627 | 0.70 | ADORA2A (0.49) | ADORA2API4KAPI4K2BPI4K2API4KB | |
| 3-Benzyladenine SCHEMBL5352368 | 0.70 | ADORA2A (0.56) | ADORA2API4KAPI4K2BPI4K2API4KB | |
| SCHEMBL5483136 | 0.70 | PKM (0.59) | ADORA2API4KAPI4K2BPI4K2API4KB | |
| SCHEMBL14105606 | 0.69 | TSHR (0.47) | ADORA2API4KAPI4K2BPI4K2API4KB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7642350-B2 | Purine derivatives | PFIZER LIMITED (GB) | 2010-01-05 | — | — | US | disclosed |
| EP-1069126-B1 | TRIAZOLOPURINE DERIVATIVES, MEDICINAL COMPOSITION CONTAINING THE DERIVATIVES, ADENOSINE A3 RECEPTOR COMPATIBILIZING AGENT, AND ASTHMATIC REMEDY | OTSUKA PHARMA CO LTD (JP) | 2003-05-28 | — | — | EP | disclosed |
| EP-0915093-B1 | AMIDE DERIVATIVES | OTSUKA PHARMA CO LTD (JP) | 2002-11-27 | — | — | EP | disclosed |
| US-6288070-B1 | Triazolopurine derivatives, medicinal composition containing the derivatives, adenosine A3 receptor compatibilizing agent, and asthmatic remedy | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 2001-09-11 | — | — | US | disclosed |
| CN-1066448-C | Amide derivatives | OTSUKA PHARMA CO LTD (JP) | 2001-05-30 | — | — | CN | disclosed |
| EP-1069126-A1 | TRIAZOLOPURINE DERIVATIVES, MEDICINAL COMPOSITION CONTAINING THE DERIVATIVES, ADENOSINE A3 RECEPTOR COMPATIBILIZING AGENT, AND ASTHMATIC REMEDY | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 2001-01-17 | — | — | EP | disclosed |
| US-6166016-A | Amide derivatives | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 2000-12-26 | — | — | US | disclosed |
| CN-1221419-A | Amide derivatives | OTSUKA PHARMA CO LTD (JP) | 1999-06-30 | — | — | CN | disclosed |
| EP-0915093-A1 | AMIDE DERIVATIVES | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1999-05-12 | — | — | EP | disclosed |