Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 2/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | NPC1 | O15118 | 4/20 | 0.44 |
| ▸ | PRKD3 | O94806 | 5/20 | 0.43 |
| ▸ | PRKCG | P05129 | 5/20 | 0.43 |
| ▸ | PRKCB | P05771 | 5/20 | 0.43 |
| ▸ | PRKCA | P17252 | 5/20 | 0.43 |
| ▸ | PRKCH | P24723 | 5/20 | 0.43 |
| ▸ | PRKCI | P41743 | 5/20 | 0.43 |
| ▸ | PRKCE | Q02156 | 5/20 | 0.43 |
| ▸ | PRKCQ | Q04759 | 5/20 | 0.43 |
| ▸ | PRKCZ | Q05513 | 5/20 | 0.43 |
| ▸ | PRKCD | Q05655 | 5/20 | 0.43 |
| ▸ | PRKD1 | Q15139 | 5/20 | 0.43 |
| ▸ | PRKACA | P17612 | 2/20 | 0.43 |
| ▸ | PRKACG | P22612 | 2/20 | 0.43 |
| ▸ | PRKACB | P22694 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6999579 | 0.82 | HEXA (0.49) | KDRCHEK1RAB9ANPC1PRKD3 | |
| SCHEMBL6996060 | 0.81 | CA12 (0.42) | KDRCHEK1RAB9ANPC1PRKD3 | |
| SCHEMBL6999914 | 0.80 | KDR (0.53) | KDRCHEK1RAB9ANPC1PRKD3 | |
| SCHEMBL7506853 | 0.76 | CHEK1 (0.53) | KDRCHEK1RAB9ANPC1PRKD3 | |
| SCHEMBL8685683 | 0.73 | KDR (0.40) | KDRCHEK1RAB9ANPC1PRKD3 | |
| SCHEMBL8478369 | 0.72 | SIRT2 (0.50) | RAB9ANPC1PRKD3PRKCGPRKCB | |
| SCHEMBL8086286 | 0.71 | KDR (0.58) | KDRCHEK1RAB9ANPC1PRKD3 | |
| SCHEMBL78989 | 0.71 | PRKD3 (0.62) | KDRCHEK1RAB9ANPC1PRKD3 | |
| SCHEMBL29415921 | 0.71 | PRKD3 (0.62) | KDRCHEK1RAB9ANPC1PRKD3 | |
| SCHEMBL30712836 | 0.71 | KDR (0.58) | KDRCHEK1RAB9ANPC1PRKD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1109785-B1 | INDOLE DERIVATIVES AND THEIR USE IN THE TREATMENT OF MALIGNANT AND OTHER DISEASES CAUSED BY PATHOLOGICAL CELL PROLIFERATION | ZENTARIS AG (DE) | 2003-01-02 | — | — | EP | disclosed |