Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 4/20 | 0.42 |
| ▸ | CA9 | Q16790 | 4/20 | 0.42 |
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 3/20 | 0.34 |
| ▸ | ACLY | P53396 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | ATR | Q13535 | 2/20 | 0.33 |
| ▸ | ATRIP | Q8WXE1 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7004177 | 0.90 | CA12 (0.44) | CA12CA9CA2CREBBPRECQL | |
| SCHEMBL7001508 | 0.89 | CA12 (0.51) | CA12CA9CA2CREBBPRECQL | |
| SCHEMBL6990241 | 0.88 | CA12 (0.40) | CA12CA9CA2CREBBPRECQL | |
| SCHEMBL7003019 | 0.81 | KDR (0.46) | CA12CA9CA2CA1KDR | |
| SCHEMBL6997478 | 0.74 | CA12 (0.60) | CA12CA9CA2CREBBPRECQL | |
| SCHEMBL6993208 | 0.70 | CA12 (0.58) | CA12CA9CA2CREBBPRECQL | |
| SCHEMBL14577242 | 0.70 | CA12 (0.49) | CA12CA9CA2RECQLACLY | |
| SCHEMBL6999579 | 0.66 | HEXA (0.49) | KDRLMNAMAPTCHEK1NPC1 | |
| SCHEMBL3558164 | 0.66 | CA12 (0.78) | CA12CA9CA2CREBBPRECQL | |
| SCHEMBL6999914 | 0.64 | KDR (0.53) | CA12CA9CA2CA1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1109785-B1 | INDOLE DERIVATIVES AND THEIR USE IN THE TREATMENT OF MALIGNANT AND OTHER DISEASES CAUSED BY PATHOLOGICAL CELL PROLIFERATION | ZENTARIS AG (DE) | 2003-01-02 | — | — | EP | disclosed |