Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 2/20 | 0.58 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 4/20 | 0.55 |
| ▸ | NPC1 | O15118 | 4/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | CASP3 | P42574 | 2/20 | 0.49 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.49 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.49 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.48 |
| ▸ | PRKCG | P05129 | 3/20 | 0.48 |
| ▸ | PRKCB | P05771 | 3/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30712836 | 0.81 | KDR (0.58) | KDRCHEK1RAB9ANPC1KDM4E | |
| SCHEMBL78989 | 0.81 | PRKD3 (0.62) | KDRCHEK1RAB9ANPC1KDM4E | |
| SCHEMBL29415921 | 0.81 | PRKD3 (0.62) | KDRCHEK1RAB9ANPC1KDM4E | |
| SCHEMBL4267947 | 0.81 | KDR (0.58) | KDRCHEK1RAB9ANPC1KDM4E | |
| SCHEMBL7506853 | 0.80 | CHEK1 (0.53) | KDRCHEK1RAB9ANPC1KDM4E | |
| SCHEMBL3959789 | 0.79 | PRKD3 (0.61) | KDRCHEK1RAB9ANPC1KDM4E | |
| SCHEMBL30968195 | 0.79 | KDR (0.61) | KDRCHEK1RAB9ANPC1KDM4E | |
| SCHEMBL8577374 | 0.79 | CCNE2 (0.51) | RAB9ANPC1KDM4EMAPTALDH1A1 | |
| SCHEMBL374022 | 0.79 | RAB9A (0.74) | KDRCHEK1RAB9ANPC1KDM4E | |
| SCHEMBL29631691 | 0.79 | RAB9A (0.74) | KDRCHEK1RAB9ANPC1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6133452-A | REACTION OF OPTIONALLY SUBSTITUTED INDOLE-3-ACETAMIDES WITH OPTIONALLY SUBSTITUTED METHYL INDOLE-3-GLYOXYL REAGENT TO PREPARE POTENT PKC INHIBITORS | ELI LILLY AND COMPANY (US) | 2000-10-17 | — | — | US | disclosed |
| US-5990319-A | REACTING INDOLYL-3-ACETAMIDE WITH INDOLYL-3-GLYOXYL REAGENT | ELI LILLY AND COMPANY (US) | 1999-11-23 | — | — | US | disclosed |
| US-5948907-A | DEPROTONATION OF THE CORRESPONDING AMIDE COMPOUND WITH A STRONG BASE | ELI LILLY AND COMPANY (US) | 1999-09-07 | — | — | US | disclosed |
| WO-1998011105-A1 | NEW PHARMACEUTICALLY ACTIVE COMPOUNDS | ASTRA AKTIEBOLAG (SE) | 1998-03-19 | — | — | WO | disclosed |
| WO-1998007693-A1 | SYNTHESIS OF BISINDOLYLMALIMIDES | ELI LILLY AND COMPANY (US) | 1998-02-26 | — | — | WO | disclosed |
| EP-0825190-A1 | Synthesis of bisindolymaleimides | ELI LILLY AND COMPANY (US) | 1998-02-25 | — | — | EP | disclosed |