Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1B | Q00975 | 1/20 | 0.50 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.50 |
| ▸ | TNIK | Q9UKE5 | 2/20 | 0.49 |
| ▸ | SIRT2 | Q8IXJ6 | 3/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6997352 | 0.89 | SIRT2 (0.47) | SIRT2KDM4EMAPTMEN1ALDH1A1 | |
| SCHEMBL7675378 | 0.84 | KDM4E (0.49) | SIRT2KDM4EMAPTMEN1ALDH1A1 | |
| SCHEMBL7666423 | 0.83 | RAB9A (0.48) | TNIKKDRKDM4EMAPTMEN1 | |
| SCHEMBL7669819 | 0.83 | KDM4E (0.48) | KDRHDAC1KDM4EMAPTMEN1 | |
| SCHEMBL5093025 | 0.82 | IKBKB (0.57) | KDM4EMAPTMEN1KMT2A | |
| SCHEMBL6995431 | 0.80 | GPR139 (0.49) | KDM4EMAPTMEN1ALDH1A1KMT2A | |
| SCHEMBL7674466 | 0.78 | HDAC1 (0.53) | TNIKHDAC1KDM4EMAPTMEN1 | |
| SCHEMBL7005038 | 0.77 | HDAC1 (0.46) | HDAC1KDM4EMAPTALDH1A1 | |
| SCHEMBL7675355 | 0.77 | KDR (0.44) | KDRKDM4EMAPTMEN1ALDH1A1 | |
| SCHEMBL7666511 | 0.77 | MAPT (0.51) | KDM4EMAPTMEN1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1294707-A2 | THIOPHENE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2003-03-26 | — | — | EP | claimed |
| US-6414013-B1 | KINASE INHIBITORS; ANTICANCER AGENTS | PHARMACIA & UPJOHN S.P.A. (IT) | 2002-07-02 | — | — | US | claimed |
| WO-2001098290-A2 | THIOPHENE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA S.P.A. (IT) | 2001-12-27 | — | — | WO | claimed |