Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 5/20 | 0.51 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 6/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.47 |
| ▸ | CHRNA1 | P02708 | 3/20 | 0.47 |
| ▸ | CHRNG | P07510 | 3/20 | 0.47 |
| ▸ | ITGA5 | P08648 | 3/20 | 0.47 |
| ▸ | CHRNB1 | P11230 | 3/20 | 0.47 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.47 |
| ▸ | CHRNB4 | P30926 | 3/20 | 0.47 |
| ▸ | CHRNA3 | P32297 | 3/20 | 0.47 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.47 |
| ▸ | CHRND | Q07001 | 3/20 | 0.47 |
| ▸ | IDO1 | P14902 | 3/20 | 0.44 |
| ▸ | KMO | O15229 | 2/20 | 0.43 |
| ▸ | CCR2 | P41597 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8152908 | 1.00 | FFAR1 (0.51) | FFAR1SLC6A2SLC6A3SLC6A4CHRNA1 | |
| SCHEMBL7003669 | 1.00 | FFAR1 (0.51) | FFAR1SLC6A2SLC6A3SLC6A4CHRNA1 | |
| SCHEMBL27426841 | 1.00 | FFAR1 (0.51) | FFAR1SLC6A2SLC6A3SLC6A4CHRNA1 | |
| SCHEMBL8152906 | 1.00 | FFAR1 (0.51) | FFAR1SLC6A2SLC6A3SLC6A4CHRNA1 | |
| SCHEMBL8149382 | 0.87 | FFAR1 (0.51) | FFAR1SLC6A2SLC6A3SLC6A4IDO1 | |
| SCHEMBL8149379 | 0.87 | FFAR1 (0.51) | FFAR1SLC6A2SLC6A3SLC6A4IDO1 | |
| SCHEMBL7002249 | 0.87 | FFAR1 (0.51) | FFAR1SLC6A2SLC6A3SLC6A4IDO1 | |
| SCHEMBL7002253 | 0.87 | FFAR1 (0.51) | FFAR1SLC6A2SLC6A3SLC6A4IDO1 | |
| SCHEMBL6998514 | 0.85 | KMO (0.54) | FFAR1SLC6A2SLC6A3SLC6A4IDO1 | |
| SCHEMBL14301510 | 0.85 | FFAR1 (0.55) | FFAR1IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0996621-B1 | TRIAZOLO[4,5-d]PYRIMIDINE DERIVATIVES AS ANTI-THROMBOTIC AGENTS | ASTRAZENECA AB (SE) | 2003-10-01 | — | — | EP | disclosed |
| US-6251910-B1 | 1,2,3-triazolo[4,5-d]pyrimidines as P2T receptor antagonists | ASTRAZENECA UK LIMITED (GB) | 2001-06-26 | — | — | US | disclosed |