Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.62 |
| ▸ | HPGD | P15428 | 6/20 | 0.62 |
| ▸ | RAB9A | P51151 | 4/20 | 0.62 |
| ▸ | TP53 | P04637 | 2/20 | 0.62 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 10/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.56 |
| ▸ | NPC1 | O15118 | 3/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.56 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.56 |
| ▸ | CASP1 | P29466 | 1/20 | 0.56 |
| ▸ | CASP7 | P55210 | 1/20 | 0.56 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.56 |
| ▸ | RELA | Q04206 | 1/20 | 0.56 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 6/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8288650 | 0.84 | ALDH1A1 (0.68) | ALDH1A1SMN1; SMN2HPGDRAB9ATP53 | |
| SCHEMBL19494329 | 0.83 | ALDH1A1 (0.45) | ALDH1A1SMN1; SMN2HPGDRAB9ATP53 | |
| SCHEMBL16263887 | 0.82 | ALDH1A1 (0.44) | ALDH1A1SMN1; SMN2HPGDRAB9ATP53 | |
| SCHEMBL6999456 | 0.79 | GRIN2C (0.79) | ALDH1A1SMN1; SMN2HPGDRAB9ATP53 | |
| SCHEMBL16263888 | 0.77 | CNR2 (0.51) | ALDH1A1SMN1; SMN2TP53HSD17B10MAPT | |
| SCHEMBL7002469 | 0.77 | ALDH1A1 (0.60) | ALDH1A1SMN1; SMN2HPGDRAB9ATP53 | |
| SCHEMBL6998127 | 0.76 | GRIN2C (0.63) | ALDH1A1SMN1; SMN2HPGDRAB9ATP53 | |
| SCHEMBL4140802 | 0.76 | KMT2A (0.56) | ALDH1A1SMN1; SMN2HPGDRAB9ATP53 | |
| SCHEMBL7003934 | 0.76 | ALDH1A1 (0.70) | ALDH1A1SMN1; SMN2HPGDRAB9ATP53 | |
| SCHEMBL19494632 | 0.75 | CNR2 (0.49) | ALDH1A1SMN1; SMN2HPGDRAB9ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1294707-A2 | THIOPHENE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2003-03-26 | — | — | EP | claimed |
| US-6414013-B1 | KINASE INHIBITORS; ANTICANCER AGENTS | PHARMACIA & UPJOHN S.P.A. (IT) | 2002-07-02 | — | — | US | claimed |
| WO-2001098290-A2 | THIOPHENE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA S.P.A. (IT) | 2001-12-27 | — | — | WO | claimed |