Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.45 |
| ▸ | KEAP1 | Q14145 | 5/20 | 0.44 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | BMP1 | P13497 | 5/20 | 0.40 |
| ▸ | CAMK2A | Q9UQM7 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | CAMK2G | Q13555 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7005000 | 0.93 | KEAP1 (0.50) | TAS2R14KEAP1NFE2L2KMT2AMEN1 | |
| SCHEMBL7003735 | 0.77 | BMP1 (0.61) | KEAP1NFE2L2BMP1 | |
| Acrylic Acid Ethyl Ester SCHEMBL7145276 | 0.77 | BMP1 (0.61) | TAS2R14BMP1ALDH1A1 | |
| SCHEMBL6999742 | 0.76 | BMP1 (0.65) | KEAP1NFE2L2KMT2AMEN1CYP3A4 | |
| SCHEMBL9843107 | 0.74 | SMN1; SMN2 (0.49) | KEAP1NFE2L2KMT2AALDH1A1MAPK1 | |
| SCHEMBL7004788 | 0.73 | BMP1 (0.66) | TAS2R14KMT2ABMP1ALDH1A1MAPK1 | |
| SCHEMBL7001435 | 0.72 | BMP1 (0.67) | TAS2R14BMP1ALDH1A1 | |
| SCHEMBL7003241 | 0.72 | KEAP1 (0.61) | KEAP1NFE2L2CYP3A4MAPTCYP2C9 | |
| SCHEMBL7004444 | 0.71 | BMP1 (0.71) | KEAP1NFE2L2CYP3A4MAPTCYP2C9 | |
| SCHEMBL7112761 | 0.69 | BMP1 (0.72) | TAS2R14KMT2AMAPTBMP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1154992-A4 | N-SUBSTITUTED ARYLSULFONYLAMINO HYDROXAMIC ACIDS USEFUL AS INHIBITORS OF C-PROTEINASE AND FOR TREATING OR PREVENTING DISORDERS RELATED TO UNREGULATED COLLAGEN PRODUCTION | FIBROGEN INC (US) | 2003-05-28 | — | — | EP | disclosed |
| EP-1154992-A1 | N-SUBSTITUTED ARYLSULFONYLAMINO HYDROXAMIC ACIDS USEFUL AS INHIBITORS OF C-PROTEINASE AND FOR TREATING OR PREVENTING DISORDERS RELATED TO UNREGULATED COLLAGEN PRODUCTION | FIBROGEN, INC. (US) | 2001-11-21 | — | — | EP | disclosed |
| WO-2000050390-A1 | N-SUBSTITUTED ARYLSULFONYLAMINO HYDROXAMIC ACIDS USEFUL AS INHIBITORS OF C-PROTEINASE AND FOR TREATING OR PREVENTING DISORDERS RELATED TO UNREGULATED COLLAGEN PRODUCTION | FIBROGEN, INC. (US) | 2000-08-31 | — | — | WO | disclosed |