Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MGMT | P16455 | 1/20 | 0.40 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.37 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6202269 | 0.85 | SMN1; SMN2 (0.44) | KDM4EALDH1A1MGMTADRA1DL3MBTL1 | |
| SCHEMBL6200741 | 0.85 | ALDH1A1 (0.39) | KDM4EALDH1A1MGMTADRA1DL3MBTL1 | |
| SCHEMBL6446623 | 0.84 | NPSR1 (0.41) | KDM4EALDH1A1MGMTADRA1DL3MBTL1 | |
| SCHEMBL6446531 | 0.83 | SMN1; SMN2 (0.40) | KDM4EALDH1A1MGMTADRA1DL3MBTL1 | |
| SCHEMBL6446672 | 0.83 | SMN1; SMN2 (0.56) | KDM4EALDH1A1MGMTADRA1DL3MBTL1 | |
| SCHEMBL7002026 | 0.81 | ALDH1A1 (0.43) | KDM4EALDH1A1MGMTL3MBTL1KMT2A | |
| SCHEMBL6995580 | 0.81 | ADRA1D (0.42) | KDM4EALDH1A1ADRA1DL3MBTL1KMT2A | |
| SCHEMBL7003298 | 0.81 | ALDH1A1 (0.36) | KDM4EALDH1A1MGMTADRA1DL3MBTL1 | |
| Hydrochloric Acid SCHEMBL7394668 | 0.81 | SMN1; SMN2 (0.36) | KDM4EALDH1A1MGMTADRA1DKMT2A | |
| SCHEMBL7000021 | 0.80 | KDM4E (0.41) | KDM4EALDH1A1MGMTL3MBTL1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1123296-B1 | PYRAZOLOPYRIMIDINONE cGMP PDE5 INHIBITORS FOR THE TREATMENT OF SEXUAL DYSFUNCTION | PFIZER LTD (GB) | 2003-09-17 | — | — | EP | disclosed |
| US-6333330-B1 | Pyrazolopyrimidinone CGMP PDE5 inhibitors for the treatment of sexual dysfunction | PFIZER INC. | 2001-12-25 | — | — | US | disclosed |
| EP-1123296-A1 | PYRAZOLOPYRIMIDINONE cGMP PDE5 INHIBITORS FOR THE TREATMENT OF SEXUAL DYSFUNCTION | Pfizer Limited (GB) | 2001-08-16 | — | — | EP | disclosed |
| WO-2000024745-A1 | PYRAZOLOPYRIMIDINONE cGMP PDE5 INHIBITORS FOR THE TREATMENT OF SEXUAL DYSFUNCTION | PFIZER LIMITED (GB) | 2000-05-04 | — | — | WO | disclosed |