Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.41 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.37 |
| ▸ | PIK3R5 | Q8WYR1 | 1/20 | 0.37 |
| ▸ | PIK3R3 | Q92569 | 1/20 | 0.37 |
| ▸ | IKBKB | O14920 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5827229 | 0.83 | ADRA1D (0.40) | ADRA1DL3MBTL1PARP10SIRT1ALDH1A1 | |
| SCHEMBL6446279 | 0.83 | USP2 (0.44) | ADRA1DL3MBTL1PARP10SIRT1ALDH1A1 | |
| SCHEMBL6447255 | 0.82 | SLC16A3 (0.42) | ADRA1DL3MBTL1PARP10SIRT1ALDH1A1 | |
| SCHEMBL6447516 | 0.81 | USP2 (0.50) | ADRA1DL3MBTL1PARP10SIRT1ALDH1A1 | |
| SCHEMBL6200427 | 0.81 | USP2 (0.42) | ADRA1DL3MBTL1PARP10SIRT1ALDH1A1 | |
| SCHEMBL7004394 | 0.81 | KDM4E (0.41) | ADRA1DL3MBTL1PARP10SIRT1ALDH1A1 | |
| SCHEMBL7004142 | 0.81 | ALDH1A1 (0.46) | ALDH1A1KMT2AMEN1PKMKDM4E | |
| SCHEMBL7003634 | 0.78 | ADRA1D (0.36) | ADRA1DL3MBTL1PARP10SIRT1ALDH1A1 | |
| SCHEMBL7004143 | 0.78 | SMN1; SMN2 (0.44) | L3MBTL1ALDH1A1KMT2AMEN1KDM4E | |
| Hydrochloric Acid SCHEMBL7991717 | 0.74 | ADRA1D (0.48) | ADRA1DL3MBTL1PARP10SIRT1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1123296-B1 | PYRAZOLOPYRIMIDINONE cGMP PDE5 INHIBITORS FOR THE TREATMENT OF SEXUAL DYSFUNCTION | PFIZER LTD (GB) | 2003-09-17 | — | — | EP | disclosed |
| US-6333330-B1 | Pyrazolopyrimidinone CGMP PDE5 inhibitors for the treatment of sexual dysfunction | PFIZER INC. | 2001-12-25 | — | — | US | disclosed |