Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 5/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 5/20 | 0.36 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.34 |
| ▸ | FEN1 | P39748 | 1/20 | 0.34 |
| ▸ | BRAF | P15056 | 3/20 | 0.34 |
| ▸ | PGR | P06401 | 1/20 | 0.33 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.33 |
| ▸ | TDP2 | O95551 | 1/20 | 0.33 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 4/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | HSD3B2 | P26439 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6994325 | 0.91 | BRAF (0.34) | PDE3BPDE3AALOX5APFEN1BRAF | |
| SCHEMBL7002918 | 0.90 | BRAF (0.36) | PDE3BPDE3ABRAFPGRNR3C2 | |
| SCHEMBL7002452 | 0.90 | ALOX5AP (0.33) | PDE3BPDE3AALOX5APFEN1BRAF | |
| SCHEMBL6996425 | 0.88 | PGR (0.34) | PGRNR3C2PTGS2 | |
| SCHEMBL6998305 | 0.87 | PGR (0.37) | PDE3BPDE3AALOX5APFEN1BRAF | |
| SCHEMBL6998059 | 0.84 | PTGS2 (0.36) | PDE3BPDE3APGRNR3C2PTGS2 | |
| SCHEMBL6999122 | 0.84 | PTGS2 (0.43) | PDE3BPDE3APGRPTGS2 | |
| SCHEMBL6998235 | 0.83 | PTGS2 (0.38) | PDE3BPDE3APGRNR3C2PTGS2 | |
| SCHEMBL7002491 | 0.82 | PTGS2 (0.38) | PDE3BPDE3APGRPTGS2 | |
| SCHEMBL6995787 | 0.82 | PGR (0.39) | BRAFPGRNR3C2PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1109799-B1 | 4,5-DIARYL-3(2H)-FURANONE DERIVATIVES AS CYCLOOXYGENASE-2 INHIBITORS | PACIFIC CORP (KR) | 2003-12-17 | — | — | EP | claimed |
| US-6492416-B1 | TREATING INFLAMMATION AND ASSOCIATED DISORDERS | PACIFIC CORPORATION (KR) | 2002-12-10 | — | — | US | claimed |
| EP-1109799-B1 | 4,5-DIARYL-3(2H)-FURANONE DERIVATIVES AS CYCLOOXYGENASE-2 INHIBITORS | PACIFIC CORP (KR) | 2003-12-17 | — | — | EP | disclosed |
| US-6492416-B1 | TREATING INFLAMMATION AND ASSOCIATED DISORDERS | PACIFIC CORPORATION (KR) | 2002-12-10 | — | — | US | disclosed |