Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | CDK4 | P11802 | 7/20 | 0.49 |
| ▸ | CCND1 | P24385 | 7/20 | 0.49 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.49 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.49 |
| ▸ | CDK2 | P24941 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | LIPG | Q9Y5X9 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7005388 | 0.95 | HPGD (0.55) | HPGDHSD17B10ALDH1A1USP2CDK4 | |
| SCHEMBL6999859 | 0.89 | KMT2A (0.50) | HPGDHSD17B10ALDH1A1USP2CDK4 | |
| SCHEMBL4573122 | 0.83 | HTR1A (0.54) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL4850347 | 0.78 | HTR1A (0.55) | HPGDHSD17B10ALDH1A1USP2CDK4 | |
| Hydrochloric Acid SCHEMBL7001168 | 0.77 | HTR2C (0.52) | HSD17B10CDK4CCND1CCNE2CCNE1 | |
| SCHEMBL7005451 | 0.74 | HTR3A (0.36) | HPGDHSD17B10ALDH1A1CDK4CCND1 | |
| SCHEMBL7005934 | 0.73 | HTR1A (0.42) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL7005560 | 0.72 | HTR3A (0.35) | HPGDHSD17B10ALDH1A1CDK4CCND1 | |
| SCHEMBL9585508 | 0.71 | CDK4 (0.48) | HPGDHSD17B10ALDH1A1USP2CDK4 | |
| SCHEMBL7002260 | 0.71 | KDM4E (0.35) | HPGDHSD17B10ALDH1A1CDK4CCND1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030105118-A1 | Tricyclic quinazolinediones | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2003-06-05 | — | — | US | disclosed |
| EP-1288216-A1 | TRICYCLIC QUINAZOLINEDIONES | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2003-03-05 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030105118-A1 | Tricyclic quinazolinediones | PARP1, PARP11, PARP2 | HPGD 267/4885HSD17B10 826/4885ALDH1A1 337/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.