Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 8/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.50 |
| ▸ | POLB | P06746 | 4/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.44 |
| ▸ | CASP6 | P55212 | 1/20 | 0.44 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | KLK7 | P49862 | 1/20 | 0.40 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7005516 | 0.97 | MEN1 (0.48) | MEN1KMT2APOLBGAAAPOBEC3A | |
| SCHEMBL7005707 | 0.75 | MAPT (0.51) | MEN1KMT2AGAACYP3A4CYP2C9 | |
| SCHEMBL7006096 | 0.73 | MEN1 (0.52) | MEN1KMT2APOLBGAAAPOBEC3A | |
| SCHEMBL8476323 | 0.72 | MEN1 (0.94) | MEN1KMT2APOLBGAAAPOBEC3A | |
| SCHEMBL2024325 | 0.71 | KMT2A (0.55) | MEN1KMT2AALDH1A1MAPK1NPC1 | |
| SCHEMBL1987728 | 0.71 | MEN1 (0.55) | MEN1KMT2AGAACYP3A4ALDH1A1 | |
| SCHEMBL12019473 | 0.70 | KMT2A (0.56) | MEN1KMT2APOLBGAACYP3A4 | |
| SCHEMBL8473549 | 0.69 | POLB (0.45) | MEN1KMT2APOLBGAAAPOBEC3A | |
| SCHEMBL7004694 | 0.69 | MAPK14 (0.50) | KDM4EMAPK14DRD4 | |
| SCHEMBL7006749 | 0.68 | TUBB4A (0.56) | MEN1KMT2AGAAKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1341761-A1 | SUBSTITUTED INDOLES, PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH INDOLES AND THEIR USE AS PPAR-$g(g) BINDING AGENTS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-09-10 | — | — | EP | disclosed |
| WO-2002030895-A1 | SUBSTITUTED INDOLES, PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH INDOLES AND THEIR USE AS PPAR-η BINDING AGENTS | SMITHKLINE BEECHAM CORPORATION (US) | 2002-04-18 | — | — | WO | disclosed |