Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 2/20 | 0.50 |
| ▸ | DRD4 | P21917 | 3/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.40 |
| ▸ | NAAA | Q02083 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7005512 | 0.97 | MAPK14 (0.47) | MAPK14DRD4BRD4DRD2HTR2A | |
| SCHEMBL7004935 | 0.79 | MAPT (0.44) | KDM4E | |
| SCHEMBL7005705 | 0.75 | MAPT (0.49) | KDM4ESMN1; SMN2 | |
| SCHEMBL6855189 | 0.70 | DRD4 (0.53) | MAPK14DRD4BRD4DRD2HTR2A | |
| SCHEMBL7002629 | 0.70 | GABRA1 (0.44) | KDM4ESMN1; SMN2 | |
| SCHEMBL7004701 | 0.69 | MEN1 (0.50) | MAPK14DRD4KDM4E | |
| SCHEMBL7006743 | 0.69 | TUBB4A (0.44) | KDM4ESMN1; SMN2 | |
| SCHEMBL7006235 | 0.68 | ALDH1A1 (0.43) | KDM4ESMN1; SMN2 | |
| SCHEMBL6851233 | 0.67 | MAPT (0.53) | MAPK14DRD4DRD2HTR2A | |
| SCHEMBL6676071 | 0.67 | MAPK14 (1.00) | MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1341761-A1 | SUBSTITUTED INDOLES, PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH INDOLES AND THEIR USE AS PPAR-$g(g) BINDING AGENTS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-09-10 | — | — | EP | disclosed |
| WO-2002030895-A1 | SUBSTITUTED INDOLES, PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH INDOLES AND THEIR USE AS PPAR-η BINDING AGENTS | SMITHKLINE BEECHAM CORPORATION (US) | 2002-04-18 | — | — | WO | disclosed |