Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 7/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.52 |
| ▸ | POLB | P06746 | 4/20 | 0.52 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.50 |
| ▸ | CASP6 | P55212 | 1/20 | 0.50 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | FFAR1 | O14842 | 7/20 | 0.43 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.41 |
| ▸ | DUT | P33316 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8476323 | 0.74 | MEN1 (0.94) | MEN1KMT2APOLBAPOBEC3ACASP6 | |
| SCHEMBL7004701 | 0.73 | MEN1 (0.50) | MEN1KMT2APOLBAPOBEC3ACASP6 | |
| SCHEMBL7005516 | 0.72 | MEN1 (0.48) | MEN1KMT2APOLBAPOBEC3ACASP6 | |
| SCHEMBL8472656 | 0.70 | MEN1 (0.56) | MEN1KMT2APOLBAPOBEC3ACASP6 | |
| SCHEMBL8472187 | 0.69 | MEN1 (0.62) | MEN1KMT2APOLBAPOBEC3ACASP6 | |
| SCHEMBL12696927 | 0.69 | DUT (0.46) | FFAR1DUT | |
| SCHEMBL8471965 | 0.69 | KDM4E (0.54) | MEN1KMT2APOLB | |
| SCHEMBL8472659 | 0.69 | MEN1 (0.59) | MEN1KMT2APOLBAPOBEC3ACASP6 | |
| SCHEMBL7006095 | 0.69 | PPARD (0.41) | FFAR1MCL1 | |
| SCHEMBL7170453 | 0.68 | FFAR4 (0.42) | FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1341761-A1 | SUBSTITUTED INDOLES, PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH INDOLES AND THEIR USE AS PPAR-$g(g) BINDING AGENTS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-09-10 | — | — | EP | disclosed |
| WO-2002030895-A1 | SUBSTITUTED INDOLES, PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH INDOLES AND THEIR USE AS PPAR-η BINDING AGENTS | SMITHKLINE BEECHAM CORPORATION (US) | 2002-04-18 | — | — | WO | disclosed |