Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 6/20 | 0.38 |
| ▸ | DRD2 | P14416 | 3/20 | 0.38 |
| ▸ | DRD3 | P35462 | 3/20 | 0.38 |
| ▸ | JAK3 | P52333 | 4/20 | 0.36 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.33 |
| ▸ | CDK4 | P11802 | 2/20 | 0.33 |
| ▸ | CCND1 | P24385 | 2/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.33 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.33 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.33 |
| ▸ | STAT5A | P42229 | 1/20 | 0.33 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7001177 | 0.85 | ADRB2 (0.44) | HTR1ADRD2DRD3JAK3ADRB2 | |
| SCHEMBL7005390 | 0.73 | CDK4 (0.53) | JAK3ADRB2OPRM1HDAC6CDK4 | |
| SCHEMBL7005717 | 0.71 | CDK4 (0.41) | HTR1ADRD2DRD3ADRB2OPRM1 | |
| SCHEMBL7004557 | 0.71 | CDK4 (0.53) | HTR1ADRD2DRD3CDK4CCND1 | |
| Hydrochloric Acid SCHEMBL7004798 | 0.70 | CDK4 (0.41) | HTR1ADRD2DRD3ADRB2OPRM1 | |
| SCHEMBL29654666 | 0.70 | EGLN2 (0.36) | HTR1ADRD2DRD3HDAC6HDAC8 | |
| Hydrochloric Acid SCHEMBL7001069 | 0.70 | HTR1A (0.71) | HTR1ADRD2DRD3 | |
| SCHEMBL7002488 | 0.68 | CDK4 (0.39) | HTR1ADRD2DRD3ADRB2OPRM1 | |
| SCHEMBL7000600 | 0.68 | HTR1A (0.45) | HTR1ADRD2DRD3CDK4CCND1 | |
| Hydrochloric Acid SCHEMBL7002842 | 0.67 | HTR1A (0.49) | HTR1ADRD2DRD3CDK4CCND1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030105118-A1 | Tricyclic quinazolinediones | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2003-06-05 | — | — | US | disclosed |
| EP-1288216-A1 | TRICYCLIC QUINAZOLINEDIONES | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2003-03-05 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030105118-A1 | Tricyclic quinazolinediones | PARP1, PARP11, PARP2 | HTR1A 135/4885DRD2 1008/4885DRD3 878/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.