Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 2/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.44 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | CDK4 | P11802 | 2/20 | 0.36 |
| ▸ | CCND1 | P24385 | 2/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.34 |
| ▸ | HTR3A | P46098 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.34 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.34 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 3/20 | 0.34 |
| ▸ | MAT2A | P31153 | 1/20 | 0.32 |
| ▸ | POLL | Q9UGP5 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7004728 | 0.85 | HTR1A (0.38) | ADRB2OPRM1CDK4CCND1HDAC6 | |
| SCHEMBL7005390 | 0.82 | CDK4 (0.53) | ADRB2OPRM1CDK4CCND1HDAC6 | |
| SCHEMBL7005717 | 0.80 | CDK4 (0.41) | ADRB2OPRM1CDK4CCND1HDAC6 | |
| Hydrochloric Acid SCHEMBL7004798 | 0.79 | CDK4 (0.41) | ADRB2OPRM1CDK4CCND1HDAC6 | |
| SCHEMBL7002488 | 0.77 | CDK4 (0.39) | ADRB2OPRM1CDK4CCND1DRD2 | |
| SCHEMBL14194309 | 0.75 | ADRB2 (0.60) | ADRB2OPRM1HTR3ADRD2DRD3 | |
| SCHEMBL10809759 | 0.75 | ADRB2 (0.60) | ADRB2OPRM1HTR3ADRD2DRD3 | |
| SCHEMBL29947861 | 0.71 | ADRB2 (0.33) | ADRB2OPRM1HTR3AKDM4E | |
| SCHEMBL6999859 | 0.71 | KMT2A (0.50) | CDK4CCND1DRD2HTR1AKDM4E | |
| SCHEMBL6581005 | 0.70 | POLL (0.39) | ADRB2OPRM1BCHEACHECDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030105118-A1 | Tricyclic quinazolinediones | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2003-06-05 | — | — | US | disclosed |
| EP-1288216-A1 | TRICYCLIC QUINAZOLINEDIONES | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2003-03-05 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030105118-A1 | Tricyclic quinazolinediones | PARP1, PARP11, PARP2 | ADRB2 1295/4885OPRM1 822/4885BCHE 3557/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.