SCHEMBL7004883

SCHEMBL7004883

Cc1cc(Oc2cccc(C(F)(F)F)c2)nc(-c2ccc(F)cc2)n1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 5/20 0.56
MAPT P10636 5/20 0.56
MAPK1 P28482 3/20 0.56
CYP1A2 P05177 2/20 0.56
CYP2C9 P11712 2/20 0.56
CYP2C19 P33261 2/20 0.56
MEN1 O00255 2/20 0.56
KMT2A Q03164 2/20 0.56
HPGD P15428 1/20 0.56
ATM Q13315 1/20 0.56
FFAR4 Q5NUL3 2/20 0.54
ABCG2 Q9UNQ0 1/20 0.48
ALDH1A1 P00352 3/20 0.46
KDM4E B2RXH2 2/20 0.46
NPSR1 Q6W5P4 4/20 0.46
SLC6A2 P23975 1/20 0.44
SLC6A4 P31645 1/20 0.44
SLC6A3 Q01959 1/20 0.44
F10 P00742 1/20 0.44
RAB9A P51151 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7006435 0.93 L3MBTL1 (0.58) L3MBTL1MAPTMAPK1CYP1A2CYP2C9
SCHEMBL7006421 0.88 MAPT (0.53) L3MBTL1MAPTMAPK1CYP1A2CYP2C9
SCHEMBL7866108 0.88 MAPT (0.56) L3MBTL1MAPTMAPK1CYP1A2CYP2C9
SCHEMBL7007084 0.85 FFAR4 (0.49) L3MBTL1MAPTMAPK1CYP1A2CYP2C9
SCHEMBL5745847 0.83 FFAR4 (0.48) L3MBTL1MAPTMAPK1CYP1A2CYP2C9
SCHEMBL6177990 0.81 FFAR4 (0.53) L3MBTL1MAPTMAPK1CYP1A2CYP2C9
SCHEMBL17623901 0.80 ALDH1A1 (0.53) L3MBTL1MAPTMAPK1CYP1A2CYP2C9
SCHEMBL7013398 0.80 MAPT (0.50) L3MBTL1MAPTMAPK1CYP1A2CYP2C9
SCHEMBL7464652 0.79 FFAR4 (0.46) L3MBTL1MAPTMAPK1CYP1A2CYP2C9
SCHEMBL17608849 0.78 ALDH1A1 (0.51) L3MBTL1MAPTCYP1A2CYP2C9CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0723960-B1 Herbicidal 2,6-disubstituted pyridines and 2,4-disubstituted pyrimidines BASF AG (DE) 2003-04-02 EP claimed
EP-0723960-A1 Herbicidal 2,6-disubstituted pyridines and 2,4-disubstituted pyrimidines American Cyanamid Company (US) 1996-07-31 EP claimed
EP-0723960-B1 Herbicidal 2,6-disubstituted pyridines and 2,4-disubstituted pyrimidines BASF AG (DE) 2003-04-02 EP disclosed
US-6066597-A Herbicidal 2-(hetero)aryloxy-6-arylpyridines and 2-aryl-4-(hetero)aryloxy-6-arylpyridines and 2-aryl-4-(hetero)aryloxypyrimidines AMERICAN CYANAMID COMPANY (US) 2000-05-23 US disclosed
US-6008161-A Herbicidal 2-(hetero)aryloxy-6-arylpyridines and 2-aryl-4-(hetero) aryloxypyrimidines AMERICAN CYANAMID COMPANY (US) 1999-12-28 US disclosed
US-5849758-A Herbicidal 2, 6-disubstituted pyridines and 2, 4-disubstituted pyrimidines AMERICAN CYANAMID COMPANY (US) 1998-12-15 US disclosed
US-5824624-A HERBICIDES WITH CARRIERS OR SURFACTANTS AMERICAN CYANAMID COMPANY (US) 1998-10-20 US disclosed
EP-0823431-A1 Herbicidal 2,6-disubstituted pyridines and 2,4-disubstituted pyrimidines American Cyanamid Company (US) 1998-02-11 EP disclosed
EP-0723960-A1 Herbicidal 2,6-disubstituted pyridines and 2,4-disubstituted pyrimidines American Cyanamid Company (US) 1996-07-31 EP disclosed