SCHEMBL7007084

SCHEMBL7007084

Cc1cc(Oc2cccc(C(F)(F)F)c2)nc(-c2ccc(F)cc2F)n1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FFAR4 Q5NUL3 1/20 0.49
MAPT P10636 5/20 0.44
NPSR1 Q6W5P4 5/20 0.44
L3MBTL1 Q9Y468 5/20 0.44
MAPK1 P28482 3/20 0.44
TSHR P16473 3/20 0.44
ALDH1A1 P00352 3/20 0.44
KDM4E B2RXH2 2/20 0.44
KMT2A Q03164 4/20 0.43
MEN1 O00255 3/20 0.43
CYP1A2 P05177 3/20 0.43
CYP2C19 P33261 3/20 0.43
CYP2C9 P11712 2/20 0.43
HPGD P15428 1/20 0.43
ATM Q13315 1/20 0.43
P2RY1 P47900 1/20 0.43
SLC6A2 P23975 1/20 0.42
SLC6A4 P31645 1/20 0.42
SLC6A3 Q01959 1/20 0.42
F10 P00742 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7004883 0.85 L3MBTL1 (0.56) FFAR4MAPTNPSR1L3MBTL1MAPK1
SCHEMBL7006435 0.80 L3MBTL1 (0.58) FFAR4MAPTNPSR1L3MBTL1MAPK1
SCHEMBL7866108 0.78 MAPT (0.56) FFAR4MAPTNPSR1L3MBTL1MAPK1
SCHEMBL17623901 0.78 ALDH1A1 (0.53) FFAR4MAPTNPSR1L3MBTL1MAPK1
SCHEMBL7006421 0.76 MAPT (0.53) FFAR4MAPTNPSR1L3MBTL1MAPK1
SCHEMBL7464652 0.76 FFAR4 (0.46) FFAR4MAPTNPSR1L3MBTL1MAPK1
SCHEMBL5745847 0.76 FFAR4 (0.48) FFAR4MAPTNPSR1L3MBTL1MAPK1
SCHEMBL17608849 0.75 ALDH1A1 (0.51) FFAR4MAPTNPSR1L3MBTL1ALDH1A1
SCHEMBL17624257 0.74 SLC6A2 (0.47) MAPTNPSR1MAPK1ALDH1A1KDM4E
SCHEMBL19317591 0.73 ALDH1A1 (0.49) FFAR4MAPTNPSR1L3MBTL1MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0723960-B1 Herbicidal 2,6-disubstituted pyridines and 2,4-disubstituted pyrimidines BASF AG (DE) 2003-04-02 EP claimed
EP-0723960-A1 Herbicidal 2,6-disubstituted pyridines and 2,4-disubstituted pyrimidines American Cyanamid Company (US) 1996-07-31 EP claimed
EP-0723960-B1 Herbicidal 2,6-disubstituted pyridines and 2,4-disubstituted pyrimidines BASF AG (DE) 2003-04-02 EP disclosed
US-6066597-A Herbicidal 2-(hetero)aryloxy-6-arylpyridines and 2-aryl-4-(hetero)aryloxy-6-arylpyridines and 2-aryl-4-(hetero)aryloxypyrimidines AMERICAN CYANAMID COMPANY (US) 2000-05-23 US disclosed
US-6008161-A Herbicidal 2-(hetero)aryloxy-6-arylpyridines and 2-aryl-4-(hetero) aryloxypyrimidines AMERICAN CYANAMID COMPANY (US) 1999-12-28 US disclosed
US-5849758-A Herbicidal 2, 6-disubstituted pyridines and 2, 4-disubstituted pyrimidines AMERICAN CYANAMID COMPANY (US) 1998-12-15 US disclosed
US-5824624-A HERBICIDES WITH CARRIERS OR SURFACTANTS AMERICAN CYANAMID COMPANY (US) 1998-10-20 US disclosed
EP-0723960-A1 Herbicidal 2,6-disubstituted pyridines and 2,4-disubstituted pyrimidines American Cyanamid Company (US) 1996-07-31 EP disclosed