Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.42 |
| ▸ | APEX1 | P27695 | 1/20 | 0.42 |
| ▸ | NSD2 | O96028 | 1/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11035155 | 0.80 | HSD17B10 (0.62) | DHODHHPGDHSD17B10MEN1ALDH1A1 | |
| SCHEMBL30228606 | 0.78 | GABRA1 (0.45) | HPGDHSD17B10MEN1ALDH1A1KMT2A | |
| SCHEMBL6517016 | 0.75 | HPGD (0.53) | DHODHHPGDHSD17B10MEN1ALDH1A1 | |
| SCHEMBL29496122 | 0.75 | KDM4E (0.63) | HPGDHSD17B10MEN1ALDH1A1KMT2A | |
| SCHEMBL318243 | 0.75 | KDM4E (0.63) | HPGDHSD17B10MEN1ALDH1A1KMT2A | |
| SCHEMBL13491530 | 0.75 | DHODH (0.54) | DHODHHPGDHSD17B10MEN1ALDH1A1 | |
| Benzoic Acid SCHEMBL28064485 | 0.74 | KDM4E (0.56) | HPGDHSD17B10ALDH1A1KDM4EMAPT | |
| Ammonia Solution, Strong SCHEMBL27264748 | 0.74 | KDM4E (0.61) | HPGDHSD17B10MEN1ALDH1A1KMT2A | |
| SCHEMBL3633330 | 0.73 | HPGD (0.57) | DHODHHPGDHSD17B10MEN1ALDH1A1 | |
| SCHEMBL29987319 | 0.73 | CDK1 (0.48) | HPGDHSD17B10MEN1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1325008-A1 | PIPERAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2003-07-09 | — | — | EP | disclosed |
| WO-2002010169-A1 | PIPERAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-02-07 | — | — | WO | disclosed |