Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | APEX1 | P27695 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | DAO | P14920 | 1/20 | 0.46 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | NSD2 | O96028 | 1/20 | 0.45 |
| ▸ | DHODH | Q02127 | 1/20 | 0.44 |
| ▸ | NGFR | P08138 | 1/20 | 0.44 |
| ▸ | EIF4A3 | P38919 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | FBP1 | P09467 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11035155 | 0.84 | HSD17B10 (0.62) | HPGDHSD17B10ALDH1A1MEN1USP2 | |
| SCHEMBL7877965 | 0.83 | KDM4E (0.56) | HPGDHSD17B10ALDH1A1MEN1KMT2A | |
| SCHEMBL3633330 | 0.83 | HPGD (0.57) | HPGDHSD17B10ALDH1A1MEN1USP2 | |
| SCHEMBL6516931 | 0.82 | MMP1 (0.50) | HPGDALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL7014604 | 0.81 | KDM4E (0.48) | HPGDHSD17B10ALDH1A1MEN1KMT2A | |
| SCHEMBL6517241 | 0.80 | HPGD (0.54) | HPGDHSD17B10ALDH1A1MEN1USP2 | |
| SCHEMBL1144995 | 0.78 | HPGD (0.62) | HPGDHSD17B10ALDH1A1MEN1USP2 | |
| SCHEMBL7414885 | 0.78 | MTNR1A (0.46) | HPGDHSD17B10ALDH1A1KMT2AKDM4E | |
| SCHEMBL5414816 | 0.77 | ALDH1A1 (0.44) | HPGDHSD17B10ALDH1A1KDM4EMAPT | |
| SCHEMBL5618186 | 0.76 | KDM4E (0.50) | HPGDHSD17B10ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050026987-A1 | CBI analogues of the duocarmycins and CC-1065 | THE SCRIPPS RESEARCH INSTITUTE (US) | 2005-02-03 | — | — | US | disclosed |
| WO-2004101767-A2 | CBI ANALOGUES OF THE DUOCARMYCINS AND CC-1065 | THE SCRIPPS RESEARCH INSTITUTE (US) | 2004-11-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050026987-A1 | CBI analogues of the duocarmycins and CC-1065 | CCNI, SP1, DCK | HPGD 4309/4885HSD17B10 4567/4885ALDH1A1 4597/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.