SCHEMBL11035155

SCHEMBL11035155

O=C(O)c1cc2cccc(C(=O)O)c2[nH]1

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSD17B10 Q99714 5/20 0.62
HPGD P15428 3/20 0.62
ALDH1A1 P00352 3/20 0.62
MEN1 O00255 1/20 0.62
USP2 O75604 1/20 0.62
KMT2A Q03164 1/20 0.62
APEX1 P27695 2/20 0.59
DHODH Q02127 1/20 0.59
KDM4E B2RXH2 5/20 0.55
MAPT P10636 2/20 0.55
DAO P14920 2/20 0.55
SRD5A2 P31213 1/20 0.55
KEAP1 Q14145 1/20 0.53
EIF4A3 P38919 1/20 0.46
TDP1 Q9NUW8 3/20 0.46
NR4A1 P22736 1/20 0.46
NR4A2 P43354 1/20 0.46
NR4A3 Q92570 1/20 0.46
PIM1 P11309 1/20 0.45
GFER P55789 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3633330 0.88 HPGD (0.57) HSD17B10HPGDALDH1A1MEN1USP2
SCHEMBL6517241 0.85 HPGD (0.54) HSD17B10HPGDALDH1A1MEN1USP2
SCHEMBL6517016 0.84 HPGD (0.53) HSD17B10HPGDALDH1A1MEN1USP2
SCHEMBL13770170 0.84 HPGD (0.60) HSD17B10HPGDALDH1A1MEN1USP2
SCHEMBL17136028 0.83 HSD17B10 (0.64) HSD17B10HPGDALDH1A1MEN1USP2
SCHEMBL2004648 0.81 KDM4E (0.63) HSD17B10HPGDALDH1A1MEN1USP2
SCHEMBL7005049 0.80 DHODH (0.48) HSD17B10HPGDALDH1A1MEN1USP2
SCHEMBL3632164 0.80 HSD17B10 (0.60) HSD17B10HPGDALDH1A1MEN1USP2
SCHEMBL3722103 0.80 HSD17B10 (0.60) HSD17B10HPGDALDH1A1MEN1USP2
SCHEMBL2808417 0.80 DHODH (0.58) HSD17B10HPGDALDH1A1DHODHKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-59222472-A None JP disclosed
JP-59222471-A None JP disclosed
JP-S59222472-A INDOLE-2,7-DICARBOXYLIC ACID COMPOUND AND ITS PREPARATION KAWAKEN FINE CHEM CO LTD 1984-12-14 JP disclosed
JP-S59222471-A PRODUCTION OF INDOLE-7-CARBOXYLIC ACID KAWAKEN FINE CHEM CO LTD 1984-12-14 JP disclosed