Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | VNN1 | O95497 | 1/20 | 0.42 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.41 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.41 |
| ▸ | CLK1 | P49759 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5739744 | 0.78 | SCD (0.42) | KDM4EPOLBGPR35KMT2AMCL1 | |
| SCHEMBL7485522 | 0.72 | SRD5A2 (0.68) | MAPTSRD5A2RXFP1KDM4EPOLB | |
| SCHEMBL7003912 | 0.72 | LTB4R2 (0.43) | MAPTKDM4EPOLBKMT2A | |
| SCHEMBL5483962 | 0.70 | MAPT (0.53) | MAPTSRD5A2RXFP1KDM4EPOLB | |
| SCHEMBL11359946 | 0.70 | ALDH1A1 (0.66) | MAPTSRD5A2RXFP1KDM4EPOLB | |
| SCHEMBL6851244 | 0.69 | PPARG (0.59) | AKR1C3AKR1C2 | |
| SCHEMBL4883914 | 0.68 | KDM4E (0.72) | KDM4EGPR35KMT2A | |
| SCHEMBL11504586 | 0.68 | RORB (0.60) | MAPTSRD5A2RXFP1KMT2AMAOB | |
| SCHEMBL7063654 | 0.68 | MEN1 (0.70) | MAPTKMT2A | |
| SCHEMBL9229493 | 0.67 | SRD5A2 (0.67) | SRD5A2RXFP1POLBVNN1AKR1C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1341761-A1 | SUBSTITUTED INDOLES, PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH INDOLES AND THEIR USE AS PPAR-$g(g) BINDING AGENTS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-09-10 | — | — | EP | disclosed |
| WO-2002030895-A1 | SUBSTITUTED INDOLES, PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH INDOLES AND THEIR USE AS PPAR-η BINDING AGENTS | SMITHKLINE BEECHAM CORPORATION (US) | 2002-04-18 | — | — | WO | disclosed |