Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Pidolic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | CAD | P27708 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.34 |
| ▸ | TPSD1 | Q9BZJ3 | 1/20 | 0.34 |
| ▸ | TPSG1 | Q9NRR2 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pidolic Acid SCHEMBL5180306 | 1.00 | LMNA (0.41) | LMNAGAACADPOLBCNR1 | |
| Pidolic Acid SCHEMBL9327901 | 0.87 | LMNA (0.39) | LMNAGAACADPOLBCNR1 | |
| Pidolic Acid SCHEMBL9327904 | 0.87 | LMNA (0.39) | LMNAGAACADPOLBCNR1 | |
| Pidolic Acid SCHEMBL4640508 | 0.86 | CAD (0.42) | LMNAGAACADPOLBCNR1 | |
| Pidolic Acid SCHEMBL14859342 | 0.85 | LMNA (0.53) | LMNAGAAPOLBCNR1DAGLA | |
| Pidolic Acid SCHEMBL15791 | 0.85 | — | — | |
| Pidolic Acid SCHEMBL10937920 | 0.85 | CAD (0.46) | LMNAGAACADPOLBSMN1; SMN2 | |
| Pidolic Acid SCHEMBL152441 | 0.85 | CAD (0.46) | LMNAGAACADPOLBSMN1; SMN2 | |
| Pidolic Acid SCHEMBL7554345 | 0.85 | CAD (0.46) | LMNAGAACADPOLBSMN1; SMN2 | |
| Pidolic Acid SCHEMBL29479230 | 0.85 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1304323-A1 | PREVENTIVES OR REMEDIES FOR ATOPIC DERMATITIS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2003-04-23 | — | — | EP | disclosed |