Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Pidolic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | PPM1B | O75688 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | PPP1CC | P36873 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL905284 | 0.94 | LMNA (0.58) | LMNAGAATSHRPPM1BPTPN1 | |
| SCHEMBL815103 | 0.94 | LMNA (0.58) | LMNAGAATSHRPPM1BPTPN1 | |
| SCHEMBL80480 | 0.94 | LMNA (0.58) | LMNAGAATSHRPPM1BPTPN1 | |
| Hydrochloric Acid SCHEMBL29400035 | 0.92 | LMNA (0.57) | LMNAGAATSHRCNR1DAGLA | |
| Isopropyl Alcohol SCHEMBL28077462 | 0.88 | LMNA (0.53) | LMNAGAATSHRCNR1DAGLA | |
| Pidolic Acid SCHEMBL7005448 | 0.85 | LMNA (0.41) | LMNAGAATSHRCNR1DAGLA | |
| Pidolic Acid SCHEMBL5180306 | 0.85 | LMNA (0.41) | LMNAGAATSHRCNR1DAGLA | |
| SCHEMBL15265428 | 0.84 | LMNA (0.49) | LMNAGAATSHRALDH1A1MAPT | |
| SCHEMBL5992612 | 0.84 | LMNA (0.49) | LMNAGAATSHRALDH1A1MAPT | |
| SCHEMBL13106060 | 0.84 | LMNA (0.49) | LMNAGAATSHRALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9694090-B2 | Process for preparing hyperpolarized substrates and method for MRI | BRACCO IMAGING S.P.A. (IT) | 2017-07-04 | — | — | US | disclosed |
| US-20130096420-A1 | Process For Preparing Hyperpolarized Substrates And Method For MRI | BRACCO IMAGING S.P.A. (IT) | 2013-04-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130096420-A1 | Process For Preparing Hyperpolarized Substrates And Method For MRI | HOGA1, HAMP, GLS2 | LMNA 390/4885GAA 1236/4885TSHR 1509/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.