Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.59 |
| ▸ | ADRA1A | P35348 | 7/20 | 0.59 |
| ▸ | ADRA1B | P35368 | 7/20 | 0.59 |
| ▸ | GLA | P06280 | 6/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.59 |
| ▸ | HPGD | P15428 | 6/20 | 0.59 |
| ▸ | GAA | P10253 | 5/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.59 |
| ▸ | ADRA1D | P25100 | 5/20 | 0.59 |
| ▸ | ADRA2B | P18089 | 4/20 | 0.59 |
| ▸ | ADRA2C | P18825 | 4/20 | 0.59 |
| ▸ | LMNA | P02545 | 3/20 | 0.59 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.59 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | SLC22A1 | O15245 | 2/20 | 0.59 |
| ▸ | ABCC4 | O15439 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7013220 | 0.88 | ADRA1A (0.56) | KDM4EADRA1AADRA1BGLAALDH1A1 | |
| SCHEMBL7013497 | 0.85 | ADRA1A (0.54) | KDM4EADRA1AADRA1BGLAALDH1A1 | |
| SCHEMBL7009182 | 0.85 | ADRA2B (0.62) | KDM4EADRA1AADRA1BGLAALDH1A1 | |
| SCHEMBL7014073 | 0.85 | ADRA1A (0.56) | KDM4EADRA1AADRA1BGLAALDH1A1 | |
| SCHEMBL7008954 | 0.85 | ADRA1A (0.53) | KDM4EADRA1AADRA1BGLAALDH1A1 | |
| SCHEMBL7011919 | 0.85 | ADRA2B (0.53) | KDM4EADRA1AADRA1BGLAALDH1A1 | |
| SCHEMBL7008333 | 0.83 | ADRA1A (0.53) | KDM4EADRA1AADRA1BGLAALDH1A1 | |
| SCHEMBL6954049 | 0.80 | ADRA1A (0.60) | KDM4EADRA1AADRA1BGLAALDH1A1 | |
| SCHEMBL7797445 | 0.79 | ADRA1B (0.93) | KDM4EADRA1AADRA1BGLAALDH1A1 | |
| Hydrochloric Acid SCHEMBL7652743 | 0.79 | KDM4E (0.61) | KDM4EADRA1AADRA1BGLAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0875506-B1 | Quinoline and quinazoline compounds useful in therapy | PFIZER LTD (GB) | 2003-02-26 | — | — | EP | disclosed |