Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER1 | P34995 | 6/20 | 0.41 |
| ▸ | PTGER4 | P35408 | 5/20 | 0.41 |
| ▸ | PTGER3 | P43115 | 5/20 | 0.41 |
| ▸ | PTGER2 | P43116 | 5/20 | 0.41 |
| ▸ | PLA2G1B | P04054 | 2/20 | 0.40 |
| ▸ | ATP4A | P20648 | 3/20 | 0.38 |
| ▸ | ATP4B | P51164 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.37 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.36 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7018281 | 0.75 | PLA2G1B (0.49) | PTGER1PTGER4PTGER3PTGER2PLA2G1B | |
| SCHEMBL7010500 | 0.74 | PLA2G1B (0.55) | PTGER1PTGER4PTGER3PTGER2PLA2G1B | |
| SCHEMBL8324082 | 0.70 | PLA2G1B (0.47) | PTGER1PTGER4PTGER3PTGER2PLA2G1B | |
| SCHEMBL7013840 | 0.69 | PLA2G1B (0.47) | PTGER1PTGER4PTGER3PTGER2PLA2G1B | |
| SCHEMBL7010964 | 0.65 | PLA2G1B (0.47) | PLA2G1BATP4AATP4BMEN1CYP1A2 | |
| SCHEMBL5510022 | 0.65 | MAPT (0.58) | MEN1MAPK1KMT2ARXRARXRB | |
| SCHEMBL201074 | 0.65 | RXRA (0.70) | PTGER1PTGER4PTGER3PTGER2MAPK1 | |
| SCHEMBL7011597 | 0.65 | ATP4A (0.44) | PLA2G1BATP4AATP4BMEN1CYP1A2 | |
| SCHEMBL7006186 | 0.65 | PLA2G1B (0.48) | PLA2G1BATP4AATP4BMEN1CYP1A2 | |
| SCHEMBL7014331 | 0.64 | ATP4A (0.49) | PLA2G1BATP4AATP4BMEN1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6645976-B1 | Nonpancreatic secretory phospholipase (sPLA2) supressors such as 2-(3-Benzyl-8-hydroxy-2-ethylindolizin-1-yl)acetamide, administered to control release of fatty acid and prevent the arachidonic acid cascade; septic shock | ELI LILLY AND COMPANY | 2003-11-11 | — | — | US | disclosed |
| EP-0772596-B1 | INDOLIZINE sPLA2 INHIBITORS | LILLY CO ELI (US) | 2003-10-01 | — | — | EP | disclosed |
| EP-0772596-A4 | INDOLIZINE sPLA2 INHIBITORS | LILLY CO ELI (US) | 1999-01-13 | — | — | EP | disclosed |
| EP-0772596-A1 | INDOLIZINE sPLA2 INHIBITORS | ELI LILLY AND COMPANY (US) | 1997-05-14 | — | — | EP | disclosed |
| WO-1996003383-A1 | INDOLIZINE sPLA2 INHIBITORS | ELI LILLY AND COMPANY (US) | 1996-02-08 | — | — | WO | disclosed |