Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G1B | P04054 | 12/20 | 0.47 |
| ▸ | PTGER1 | P34995 | 4/20 | 0.43 |
| ▸ | PTGER4 | P35408 | 4/20 | 0.43 |
| ▸ | PTGER3 | P43115 | 4/20 | 0.43 |
| ▸ | PTGER2 | P43116 | 4/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | PLA2G2A | P14555 | 4/20 | 0.39 |
| ▸ | PLA2G2E | Q9NZK7 | 3/20 | 0.39 |
| ▸ | PLA2G5 | P39877 | 2/20 | 0.39 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.39 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7010577 | 0.87 | HTR1A (0.46) | PLA2G1BHTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL8022953 | 0.86 | PLA2G1B (0.64) | PLA2G1BPLA2G2APLA2G2EPLA2G5PLA2G10 | |
| SCHEMBL7018281 | 0.83 | PLA2G1B (0.49) | PLA2G1BPTGER1PTGER4PTGER3PTGER2 | |
| SCHEMBL7010592 | 0.83 | PLA2G1B (0.61) | PLA2G1BPLA2G2APLA2G2EPLA2G5PLA2G10 | |
| SCHEMBL7010500 | 0.82 | PLA2G1B (0.55) | PLA2G1BPTGER1PTGER4PTGER3PTGER2 | |
| SCHEMBL7009863 | 0.80 | PLA2G1B (0.66) | PLA2G1BPLA2G2APLA2G2EPLA2G5PLA2G10 | |
| SCHEMBL7013923 | 0.79 | HTR1A (0.43) | PLA2G1BHTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL8324753 | 0.77 | RXRA (0.42) | PLA2G1BPTGER1PTGER4PTGER3PTGER2 | |
| SCHEMBL8323100 | 0.74 | PLA2G1B (0.83) | PLA2G1BPLA2G2APLA2G2EPLA2G5PLA2G10 | |
| SCHEMBL7012834 | 0.73 | PLA2G1B (0.84) | PLA2G1BPLA2G2APLA2G2EPLA2G5PLA2G10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0772596-A4 | INDOLIZINE sPLA2 INHIBITORS | LILLY CO ELI (US) | 1999-01-13 | — | — | EP | disclosed |
| EP-0772596-A1 | INDOLIZINE sPLA2 INHIBITORS | ELI LILLY AND COMPANY (US) | 1997-05-14 | — | — | EP | disclosed |
| WO-1996003383-A1 | INDOLIZINE sPLA2 INHIBITORS | ELI LILLY AND COMPANY (US) | 1996-02-08 | — | — | WO | disclosed |