Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TUBB4A | P04350 | 1/20 | 0.69 |
| ▸ | TUBB | P07437 | 1/20 | 0.69 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.69 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.69 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.69 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.69 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.69 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.69 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.69 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.69 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.69 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.69 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.69 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.69 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.69 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.52 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.52 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.52 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.52 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7003886 | 0.86 | TUBB4A (0.77) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL7001049 | 0.86 | TUBB4A (0.69) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL5503343 | 0.82 | TUBB4A (1.00) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL25904024 | 0.78 | ALDH1A1 (0.68) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL6595921 | 0.78 | GABRA1 (0.63) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL2203795 | 0.77 | GABRA1 (0.64) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL829647 | 0.77 | GABRA1 (0.64) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL8938320 | 0.77 | TUBB4A (0.75) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL5273322 | 0.77 | GABRA1 (0.49) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL8540181 | 0.76 | ALDH1A1 (0.67) | GABRA1GABRG2GABRB3GABRA5GABRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1341761-A1 | SUBSTITUTED INDOLES, PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH INDOLES AND THEIR USE AS PPAR-$g(g) BINDING AGENTS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-09-10 | — | — | EP | disclosed |
| WO-2002030895-A1 | SUBSTITUTED INDOLES, PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH INDOLES AND THEIR USE AS PPAR-η BINDING AGENTS | SMITHKLINE BEECHAM CORPORATION (US) | 2002-04-18 | — | — | WO | disclosed |