Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 14/20 | 0.51 |
| ▸ | MMP1 | P03956 | 14/20 | 0.51 |
| ▸ | MMP9 | P14780 | 12/20 | 0.51 |
| ▸ | ADAM17 | P78536 | 9/20 | 0.48 |
| ▸ | MMP3 | P08254 | 3/20 | 0.35 |
| ▸ | MMP7 | P09237 | 2/20 | 0.35 |
| ▸ | MMP2 | P08253 | 2/20 | 0.35 |
| ▸ | MMP8 | P22894 | 1/20 | 0.35 |
| ▸ | MMP14 | P50281 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7009421 | 0.83 | MMP9 (0.48) | MMP13MMP1MMP9ADAM17MMP2 | |
| SCHEMBL7011337 | 0.80 | MMP9 (0.45) | MMP13MMP1MMP9ADAM17MMP2 | |
| SCHEMBL7014631 | 0.72 | MMP13 (0.52) | MMP13MMP1MMP9ADAM17MMP2 | |
| SCHEMBL7006547 | 0.71 | MMP9 (0.54) | MMP13MMP1MMP9ADAM17 | |
| SCHEMBL7013255 | 0.70 | MMP13 (0.58) | MMP13MMP1MMP9ADAM17MMP2 | |
| SCHEMBL7009856 | 0.69 | MMP9 (0.55) | MMP13MMP1MMP9ADAM17MMP3 | |
| SCHEMBL7012919 | 0.69 | MMP9 (0.76) | MMP13MMP1MMP9ADAM17ALDH1A1 | |
| SCHEMBL7012226 | 0.68 | MMP9 (0.48) | MMP13MMP1MMP9ADAM17MMP2 | |
| SCHEMBL7009419 | 0.64 | KMT2A (0.38) | MMP1ALDH1A1MEN1KMT2A | |
| SCHEMBL7010946 | 0.63 | MMP13 (0.59) | MMP13MMP1MMP9ADAM17MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1021413-B1 | THE PREPARATION AND USE OF ORTHO-SULFONAMIDO BICYCLIC HETEROARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS | WYETH CORP (US) | 2003-06-11 | — | — | EP | claimed |