Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 14/20 | 0.55 |
| ▸ | MMP1 | P03956 | 14/20 | 0.55 |
| ▸ | MMP13 | P45452 | 13/20 | 0.55 |
| ▸ | ADAM17 | P78536 | 10/20 | 0.49 |
| ▸ | MMP3 | P08254 | 1/20 | 0.34 |
| ▸ | MMP7 | P09237 | 1/20 | 0.34 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.34 |
| ▸ | RAF1 | P04049 | 1/20 | 0.34 |
| ▸ | MMP2 | P08253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7012209 | 0.83 | MMP9 (0.56) | MMP9MMP1MMP13ADAM17MAPK13 | |
| SCHEMBL7012919 | 0.83 | MMP9 (0.76) | MMP9MMP1MMP13ADAM17MAPK13 | |
| SCHEMBL7015443 | 0.80 | MMP9 (0.53) | MMP9MMP1MMP13ADAM17MMP2 | |
| SCHEMBL7014631 | 0.79 | MMP13 (0.52) | MMP9MMP1MMP13ADAM17MMP2 | |
| SCHEMBL7010946 | 0.78 | MMP13 (0.59) | MMP9MMP1MMP13ADAM17MMP3 | |
| SCHEMBL7006547 | 0.77 | MMP9 (0.54) | MMP9MMP1MMP13ADAM17 | |
| SCHEMBL7013255 | 0.75 | MMP13 (0.58) | MMP9MMP1MMP13ADAM17MMP2 | |
| SCHEMBL7006515 | 0.75 | MMP9 (0.76) | MMP9MMP1MMP13ADAM17MMP3 | |
| SCHEMBL7011475 | 0.72 | MMP1 (0.60) | MMP9MMP1MMP13ADAM17 | |
| SCHEMBL7006372 | 0.69 | MMP13 (0.51) | MMP9MMP1MMP13ADAM17MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1021413-B1 | THE PREPARATION AND USE OF ORTHO-SULFONAMIDO BICYCLIC HETEROARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS | WYETH CORP (US) | 2003-06-11 | — | — | EP | claimed |