Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA9 | Q16790 | 3/20 | 0.46 |
| ▸ | CA1 | P00915 | 2/20 | 0.46 |
| ▸ | CA2 | P00918 | 2/20 | 0.46 |
| ▸ | CA12 | O43570 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3070549 | 0.83 | KMT2A (0.56) | CA9CA1CA2CA12ALDH1A1 | |
| SCHEMBL7012464 | 0.82 | SMN1; SMN2 (0.53) | CA9CA1CA2CA12ALDH1A1 | |
| SCHEMBL13895359 | 0.80 | KMT2A (0.49) | CA9CA1CA2CA12ALDH1A1 | |
| SCHEMBL8837432 | 0.77 | KMT2A (0.46) | CA9CA1CA2CA12ALDH1A1 | |
| SCHEMBL3566466 | 0.77 | CA12 (0.54) | CA9CA1CA2CA12ALDH1A1 | |
| SCHEMBL6138556 | 0.77 | SMN1; SMN2 (0.57) | ALDH1A1MAPTLMNAHTTSMN1; SMN2 | |
| SCHEMBL7230521 | 0.77 | KMT2A (0.46) | CA9CA1CA2CA12ALDH1A1 | |
| SCHEMBL5660298 | 0.76 | LPL (0.52) | CA1CA2ALDH1A1MEN1KMT2A | |
| SCHEMBL2112943 | 0.76 | CA2 (0.65) | CA9CA1CA2CA12ALDH1A1 | |
| SCHEMBL344067 | 0.76 | CA2 (0.61) | CA2ALDH1A1KMT2AMAPTHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0673937-B1 | BICYCLIC HETEROCYCLIC SULFONAMIDE AND SULFONIC ESTER DERIVATIVES | EISAI CO LTD (JP) | 2003-11-26 | — | — | EP | disclosed |
| EP-0673937-A1 | BICYCLIC HETEROCYCLIC SULFONAMIDE AND SULFONIC ESTER DERIVATIVES | Eisai Co., Ltd. (JP) | 1995-09-27 | — | — | EP | disclosed |