Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | MEN1 | O00255 | 4/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | LMNA | P02545 | 4/20 | 0.51 |
| ▸ | HTT | P42858 | 3/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 5/20 | 0.49 |
| ▸ | CA2 | P00918 | 5/20 | 0.49 |
| ▸ | CA9 | Q16790 | 5/20 | 0.49 |
| ▸ | CA12 | O43570 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3061918 | 0.84 | ALDH1A1 (0.53) | SMN1; SMN2ALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL7006424 | 0.82 | CA9 (0.46) | SMN1; SMN2ALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL4775268 | 0.79 | SMN1; SMN2 (0.55) | SMN1; SMN2ALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL11170496 | 0.79 | LMNA (0.62) | SMN1; SMN2ALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL15652547 | 0.79 | CA1 (0.57) | SMN1; SMN2ALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL14719879 | 0.78 | MEN1 (0.77) | SMN1; SMN2ALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL617094 | 0.77 | CA2 (0.64) | SMN1; SMN2ALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL9754483 | 0.77 | MEN1 (0.75) | SMN1; SMN2ALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL11582128 | 0.77 | ALDH1A1 (0.52) | SMN1; SMN2ALDH1A1MEN1KMT2ATSHR | |
| SCHEMBL5187852 | 0.75 | MEN1 (0.53) | SMN1; SMN2ALDH1A1MEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0673937-B1 | BICYCLIC HETEROCYCLIC SULFONAMIDE AND SULFONIC ESTER DERIVATIVES | EISAI CO LTD (JP) | 2003-11-26 | — | — | EP | disclosed |
| EP-0673937-A1 | BICYCLIC HETEROCYCLIC SULFONAMIDE AND SULFONIC ESTER DERIVATIVES | Eisai Co., Ltd. (JP) | 1995-09-27 | — | — | EP | disclosed |