Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.42 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.41 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.41 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30255617 | 0.84 | MEN1 (0.37) | KEAP1NFE2L2TSHRALDH1A1TP53 | |
| SCHEMBL8727193 | 0.84 | ALDH1A1 (0.40) | KEAP1NFE2L2TSHRALDH1A1TP53 | |
| SCHEMBL5591588 | 0.84 | MEN1 (0.37) | KEAP1NFE2L2TSHRALDH1A1TP53 | |
| SCHEMBL8683261 | 0.84 | KEAP1 (0.44) | KEAP1NFE2L2TSHRALDH1A1TP53 | |
| SCHEMBL7005963 | 0.83 | AKR1C2 (0.52) | KEAP1NFE2L2TSHRALDH1A1TP53 | |
| SCHEMBL29376622 | 0.83 | KEAP1 (0.52) | KEAP1NFE2L2TSHRALDH1A1TP53 | |
| SCHEMBL8679913 | 0.83 | KEAP1 (0.42) | KEAP1NFE2L2TSHRALDH1A1TP53 | |
| SCHEMBL2434231 | 0.83 | KEAP1 (0.52) | KEAP1NFE2L2TSHRALDH1A1TP53 | |
| SCHEMBL23513273 | 0.82 | NOTUM (0.42) | KEAP1NFE2L2TSHRALDH1A1TP53 | |
| SCHEMBL23496860 | 0.82 | MAP2K1 (0.39) | KEAP1NFE2L2TSHRALDH1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0894784-B1 | 4-FLUOROSALICYLIC ACID DERIVATIVES AND PROCESS FOR PRODUCING THE SAME | IHARA CHEMICAL IND CO (JP) | 2003-01-08 | — | — | EP | disclosed |
| US-6166246-A | 4-fluorosalicyclic acid derivative and process for production thereof | IHARA CHEMICAL INDUSTRY CO., LTD. (JP) | 2000-12-26 | — | — | US | disclosed |
| EP-0757028-B1 | Process for the preparation of aromatic carbonic acid esters | CLARIANT GMBH (DE) | 1999-12-29 | — | — | EP | disclosed |
| US-5874608-A | Process for the preparation of esters of aromatic carboxylic acid | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-02-23 | — | — | US | disclosed |
| EP-0894784-A1 | 4-FLUOROSALICYLIC ACID DERIVATIVES AND PROCESS FOR PRODUCING THE SAME | IHARA CHEMICAL INDUSTRY Co., Ltd. (JP) | 1999-02-03 | — | — | EP | disclosed |
| US-5777181-A | 2, 4, 5-trihalogeno- and 2, 3, 4, 5-tetrahalogenobenzene derivatives | BAYER AKTIENGESELLSCHAFT (DE) | 1998-07-07 | — | — | US | disclosed |
| EP-0811601-A1 | Process for the preparation of aromatic carbonic acid esters | Clariant GmbH (DE) | 1997-12-10 | — | — | EP | disclosed |
| EP-0757028-A1 | Process for the preparation of aromatic carbonic acid esters | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-02-05 | — | — | EP | disclosed |
| US-5565614-A | FLUORINATION | BAYER AKTIENGESELLSCHAFT (DE) | 1996-10-15 | — | — | US | disclosed |
| US-5530158-A | CHEMICAL INTERMEDIATE FOR ANTIBACTERIALS | BAYER AKTIENGESELLSCHAFT (DE) | 1996-06-25 | — | — | US | disclosed |
| US-5362909-A | Two stage fluorination | BAYER AKTIENGESELLSCHAFT (DE) | 1994-11-08 | — | — | US | disclosed |
| EP-0296479-B1 | Fluorobenzoates and process for their production | IHARA CHEMICAL IND CO (JP) | 1994-03-30 | — | — | EP | disclosed |
| US-5200548-A | Intermediates for bactericides | BAYER AKTIENGESELLSCHAFT (DE) | 1993-04-06 | — | — | US | disclosed |
| US-5072038-A | Chemical intermediates for bactericides | BAYER AKTIENGESELLSCHAFT (DE) | 1991-12-10 | — | — | US | disclosed |
| US-4916253-A | Fluorobenzoates and process for their production | IHARA CHEMICAL INDUSTRY COMPANY, LTD. (JP) | 1990-04-10 | — | — | US | disclosed |
| EP-0296479-A2 | Fluorobenzoates and process for their production | IHARA CHEMICAL INDUSTRY Co., Ltd. (JP) | 1988-12-28 | — | — | EP | disclosed |
| EP-0164619-B1 | 2,4,5-TRIHALO OR 2,3,4,5-TETRAHALO BENZENE DERIVATIVES AND PROCESS FOR PRODUCING THEM | BAYER AG (DE) | 1988-10-12 | — | — | EP | disclosed |