Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 20/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7007275 | 0.88 | CRHR1 (0.55) | CRHR1 | |
| SCHEMBL7007793 | 0.83 | CRHR1 (0.47) | CRHR1 | |
| SCHEMBL7004385 | 0.79 | MAPT (0.37) | CRHR1 | |
| SCHEMBL7006275 | 0.79 | LMNA (0.35) | CRHR1 | |
| SCHEMBL7004989 | 0.72 | GAA (0.33) | CRHR1 | |
| SCHEMBL7008469 | 0.72 | CRHR1 (0.46) | CRHR1 | |
| SCHEMBL7007327 | 0.72 | CRHR1 (0.49) | CRHR1 | |
| SCHEMBL7005620 | 0.72 | NCF1 (0.46) | — | |
| SCHEMBL7009295 | 0.72 | CRHR1 (0.44) | CRHR1 | |
| SCHEMBL7010054 | 0.72 | CDK5 (0.33) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1086103-B1 | PYRIDO 2,3-B]INDOLIZINE DERIVATIVES AND AZA ANALOGUES THEREOF; CRF 1 SPECIFIC LIGANDS | NEUROGEN CORP (US) | 2003-05-02 | — | — | EP | claimed |
| US-6194574-B1 | SELECTIVELY BIND TO CORTICOTROPIN-RELEASING FACTOR (CRF1) RECEPTORS; FOR TREATING STRESS RELATED DISORDERS SUCH AS POST TRAUMATIC STRESS DISORDER (PTSD) AS WELL AS DEPRESSION, HEADACHE AND ANXIETY | NEUROGEN CORPORATION | 2001-02-27 | — | — | US | claimed |
| EP-1086103-B1 | PYRIDO 2,3-B]INDOLIZINE DERIVATIVES AND AZA ANALOGUES THEREOF; CRF 1 SPECIFIC LIGANDS | NEUROGEN CORP (US) | 2003-05-02 | — | — | EP | disclosed |
| US-6495686-B2 | THERAPY FOR PSYCHOLOGICAL DISORDERS | NEUROGEN CORPORATION | 2002-12-17 | — | — | US | disclosed |
| US-6194574-B1 | SELECTIVELY BIND TO CORTICOTROPIN-RELEASING FACTOR (CRF1) RECEPTORS; FOR TREATING STRESS RELATED DISORDERS SUCH AS POST TRAUMATIC STRESS DISORDER (PTSD) AS WELL AS DEPRESSION, HEADACHE AND ANXIETY | NEUROGEN CORPORATION | 2001-02-27 | — | — | US | disclosed |