Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 2/20 | 0.59 |
| ▸ | HTR2A | P28223 | 2/20 | 0.59 |
| ▸ | HTR2B | P41595 | 1/20 | 0.59 |
| ▸ | KMO | O15229 | 1/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.37 |
| ▸ | PDE9A | O76083 | 1/20 | 0.36 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.36 |
| ▸ | PDE1A | P54750 | 1/20 | 0.36 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.36 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7997898 | 0.79 | KMO (0.46) | HTR2CHTR2AHTR2BKMOADRA2A | |
| SCHEMBL14746650 | 0.75 | HTR2A (0.50) | HTR2CHTR2AHTR2BKMOMAPT | |
| SCHEMBL13113212 | 0.75 | HTR2A (0.59) | HTR2CHTR2AHTR2BCHRM2CHRM1 | |
| SCHEMBL31079387 | 0.74 | HTR2C (1.00) | HTR2CHTR2AHTR2BCHRM2CHRM1 | |
| SCHEMBL6364886 | 0.74 | HTR2C (1.00) | HTR2CHTR2AHTR2BCHRM2CHRM1 | |
| SCHEMBL3662545 | 0.73 | HTR2A (0.57) | HTR2CHTR2AHTR2BMAPTSMN1; SMN2 | |
| SCHEMBL3861479 | 0.72 | DYRK1A (0.39) | HTR2CHTR2AHTR2BADRA2AADRA1A | |
| SCHEMBL7008755 | 0.72 | CA1 (0.46) | HTR2CHTR2AHTR2BKMOMAPT | |
| SCHEMBL28707949 | 0.71 | HTR2A (0.67) | HTR2CHTR2AHTR2BCHRM2CHRM1 | |
| SCHEMBL14349825 | 0.70 | KMO (0.58) | HTR2CHTR2AHTR2BKMOMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268438-A1 | 6-HYDROXY-INDAZOLE DERIVATIVES FOR TREATING GLAUCOMA | Alcon, Inc (CH) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001070702-A1 | 6-HYDROXY-INDAZOLE DERIVATIVES FOR TREATING GLAUCOMA | ALCON, INC. (CH) | 2001-09-27 | — | — | WO | disclosed |