Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.72 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.72 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.72 |
| ▸ | RAB9A | P51151 | 5/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.68 |
| ▸ | NPC1 | O15118 | 4/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.67 |
| ▸ | RECQL | P46063 | 1/20 | 0.65 |
| ▸ | LTA4H | P09960 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5232192 | 0.84 | NR1H4 (0.61) | MEN1KMT2ACYP1A2CYP2C19RAB9A | |
| SCHEMBL3424405 | 0.83 | MEN1 (0.74) | MEN1KMT2ACYP1A2CYP2C19RAB9A | |
| SCHEMBL8706869 | 0.83 | MEN1 (0.74) | MEN1KMT2ACYP1A2CYP2C19RAB9A | |
| SCHEMBL4964241 | 0.81 | NPC1 (1.00) | MEN1KMT2ARAB9ASMN1; SMN2NPC1 | |
| SCHEMBL9725077 | 0.81 | MEN1 (0.72) | MEN1KMT2ACYP1A2CYP2C19RAB9A | |
| SCHEMBL11492866 | 0.80 | RAB9A (0.75) | MEN1KMT2ACYP1A2CYP2C19RAB9A | |
| SCHEMBL864192 | 0.79 | ALDH1A1 (0.60) | MEN1KMT2ACYP1A2CYP2C19RAB9A | |
| SCHEMBL4666205 | 0.79 | RAB9A (0.74) | MEN1KMT2ACYP1A2CYP2C19RAB9A | |
| SCHEMBL4979973 | 0.79 | MEN1 (0.69) | MEN1KMT2ACYP1A2CYP2C19RAB9A | |
| SCHEMBL22192264 | 0.78 | RAB9A (0.94) | MEN1KMT2ARAB9ASMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1339701-A1 | HETEROARYL ALKYL PIPERAZINE DERIVATIVES AS FATTY ACID OXIDATION INHIBITORS | CV THERAPEUTICS, INC. (US) | 2003-09-03 | — | — | EP | disclosed |
| WO-2002064576-A1 | HETEROARYL ALKYL PIPERAZINE DERIVATIVES AS FATTY ACID OXIDATION INHIBITORS | CV THERAPEUTICS, INC. (US) | 2002-08-22 | — | — | WO | disclosed |