Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 3/20 | 0.41 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.41 |
| ▸ | PRKCB | P05771 | 2/20 | 0.40 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.40 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.40 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | PRKCG | P05129 | 1/20 | 0.40 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | CDK4 | P11802 | 1/20 | 0.40 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.40 |
| ▸ | PRKCA | P17252 | 1/20 | 0.40 |
| ▸ | PRKACA | P17612 | 1/20 | 0.40 |
| ▸ | PRKACG | P22612 | 1/20 | 0.40 |
| ▸ | PRKACB | P22694 | 1/20 | 0.40 |
| ▸ | CCND1 | P24385 | 1/20 | 0.40 |
| ▸ | PRKCH | P24723 | 1/20 | 0.40 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7011009 | 0.81 | SIRT2 (0.47) | SIRT2SIRT1PRKCBPRKD3CCNB2 | |
| SCHEMBL7010190 | 0.79 | NT5E (0.45) | SIRT2SIRT1PRKCBPRKD3CCNB2 | |
| SCHEMBL7010672 | 0.74 | SIRT2 (0.48) | SIRT2SIRT1PRKCBPRKD3CCNB2 | |
| SCHEMBL8520286 | 0.72 | HSP90AA1 (0.54) | SIRT2SIRT1MEN1KMT2AHSP90AA1 | |
| SCHEMBL6976408 | 0.67 | MEN1 (0.40) | SIRT2SIRT1PRKCBPRKD3CCNB2 | |
| SCHEMBL20561874 | 0.64 | NR4A2 (0.49) | SIRT2SIRT1PRKCBPRKD3CCNB2 | |
| SCHEMBL6984020 | 0.64 | CDK4 (0.48) | SIRT2SIRT1PRKCBPRKD3CCNB2 | |
| SCHEMBL1202543 | 0.63 | IMPDH2 (0.63) | SIRT2SIRT1PRKCBPRKD3CCNB2 | |
| SCHEMBL17861173 | 0.63 | ATM (0.45) | SIRT2SIRT1MEN1KMT2AMAPT | |
| SCHEMBL17179219 | 0.63 | NR4A2 (0.50) | SIRT2SIRT1PRKCBPRKD3CCNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1042317-B1 | Indole derivatives as PKC-inhiboitors | ASTRAZENECA AB (SE) | 2003-05-14 | — | — | EP | claimed |
| EP-1028955-B1 | PYRIMIDINONE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SMITHKLINE BEECHAM PLC (GB) | 2003-07-16 | — | — | EP | disclosed |
| EP-1042317-B1 | Indole derivatives as PKC-inhiboitors | ASTRAZENECA AB (SE) | 2003-05-14 | — | — | EP | disclosed |