SCHEMBL7006987

SCHEMBL7006987

NCCCN1CCCCC1OC(c1ccccc1)c1ccccc1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRM2 P08172 2/20 0.43
ADRA2A P08913 2/20 0.43
CHRM1 P11229 2/20 0.43
DRD1 P21728 2/20 0.43
SLC6A2 P23975 2/20 0.43
ADRA1A P35348 2/20 0.43
OPRM1 P35372 2/20 0.43
DRD3 P35462 2/20 0.43
SLC6A3 Q01959 2/20 0.43
KCNH2 Q12809 2/20 0.43
HTR1A P08908 1/20 0.43
CYP2D6 P10635 1/20 0.43
HRH3 Q9Y5N1 1/20 0.43
MAPK1 P28482 1/20 0.43
HTR2A P28223 2/20 0.40
HRH1 P35367 2/20 0.40
CHRM4 P08173 1/20 0.40
CHRM5 P08912 1/20 0.40
DRD2 P14416 1/20 0.40
ADRA2B P18089 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8938226 0.83 HRH3 (0.40) CHRM2ADRA2ACHRM1DRD1SLC6A2
SCHEMBL6863712 0.82 SIGMAR1 (0.44) CHRM2ADRA2ACHRM1DRD1SLC6A2
SCHEMBL8938621 0.80 SIGMAR1 (0.41) CHRM2ADRA2ACHRM1DRD1SLC6A2
SCHEMBL8938201 0.78 HRH3 (0.53) CHRM2ADRA2ACHRM1DRD1SLC6A2
SCHEMBL8938542 0.78 HRH3 (0.49) CHRM2ADRA2ACHRM1DRD1SLC6A2
SCHEMBL8938514 0.78 HRH3 (0.42) HRH3
SCHEMBL8938361 0.78 GBA1 (0.41) CHRM2ADRA2ACHRM1DRD1SLC6A2
SCHEMBL8938195 0.77 SIGMAR1 (0.44) HRH3OPRK1SIGMAR1
SCHEMBL3910868 0.77 HPGDS (0.43) CHRM2ADRA2ACHRM1DRD1SLC6A2
SCHEMBL8938454 0.77 HRH3 (0.54) CHRM2ADRA2ACHRM1DRD1SLC6A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1123936-B1 FUSED PYRIDAZINE DERIVATIVES, PROCESS FOR THE PREPARATION OF THE SAME AND USES THEREOF TAKEDA CHEMICAL INDUSTRIES LTD (JP) 2003-12-10 EP disclosed